摘要
目的探讨神经节苷脂注射液联合全身亚低温序贯高压氧治疗新生儿缺血缺氧性脑病(HIE)的效果。方法取2022年3月至2024年6月时间段,本院收治的新生儿HIE102例,根据入院时间先后顺序分组,先入院的51例采取常规治疗+神经节苷脂注射液,后入院的51例在对照组基础上加全身亚低温序贯高压氧治疗,比较两组治疗效果。结果与对照组比较,观察组临床表现恢复时间均更短,治疗6个月后MDI、PDI评分更高(P<0.05);与治疗后对照组比较,观察组HIF-1α、ICAM-1更低,NGF更高(P<0.05)。结论神经节苷脂注射液联合全身亚低温序贯高压氧治疗新生儿HIE效果满意,能够促进临床症状快速恢复,也有助于神经功能修复,利于患儿预后。
Objective To investigate the effect of ganglioside injection combined with systemic hypothermia sequential hyperbaric oxygen therapy on neonatal ischemic hypoxic encephalopathy(HIE).Methods From March 2022 to June 2024,102 newborns with HIE admitted to our hospital were divided into two groups according to the order of admission time.The first 51 cases were treated with conventional therapy and ganglioside injection,while the second 51 cases were treated with systemic hypothermia and sequential hyperbaric oxygen therapy in addition to the control group.The treatment effects of the two groups were compared.Results Compared with the control group,the observation group had a shorter recovery time for clinical manifestations and higher MDI and PDI scores after 6 months of treatment(P<0.05).Compared with the control group after treatment,the observation group had lower levels of HIF-1αand ICAM-1,and higher levels of NGF(P<0.05).Conclusion The combination of ganglioside injection and systemic hypothermia sequential hyperbaric oxygen therapy is effective in treating neonatal HIE,promoting rapid recovery of clinical symptoms and aiding in neurological function repair,which is beneficial for the prognosis of pediatric patients.
作者
曾婷婷
ZENG Ting-ting(Department of Pediatric Neurology,Nanyang Central Hospital,Nanyang 473000,Henan Province,China)
出处
《罕少疾病杂志》
2025年第4期6-8,共3页
Journal of Rare and Uncommon Diseases
关键词
神经节苷脂注射液
全身亚低温
高压氧
新生儿缺血缺氧性脑病
神经功能
Ganglioside Injection
Whole Body Hypothermia
Hyperbaric Oxygen
Neonatal Ischemic Hypoxic Encephalopathy
Neurological Function
