摘要
目的探讨炭素行业职业接触工人肺功能损伤的影响因素。方法于2024年1月,采用判断抽样方法,以炭素行业职业接触工人230人为研究对象,按职业健康检查有无肺功能损伤分为异常组和正常组。采用问卷收集炭素行业工人基本信息,测定其肺功能,采集班后尿液样本及血液样本进行1-羟基芘、1-羟基萘、2-羟基萘浓度及外周血淋巴细胞彗星尾部DNA百分含量和Olive尾距的测定。采用Mann-Whitney检验和t检验比较两组工人肺功能、尿液及血液样本各指标的差异,肺功能损伤的影响因素采用logistic回归分析。结果肺功能正常组(n=118)炭素行业职业接触工人用力肺活量(FVC)%[88%(86%,92%)]、第1秒用力呼气量(FEV 1)%[92%(88%,95%)]、FEV 1.0/FVC%[96%(91%,102%)]均明显高于肺功能异常组(n=112)[83%(80%,87%)、84%(80%,88%)、86%(79%,91%)],差异均有统计学意义(P<0.05);肺功能异常组工人1-羟基芘[9.28(2.96,25.94)μg/g]、1-羟基萘[2.48(1.47,4.37)μg/g]、尾部DNA百分含量[11.83%(5.30%,21.45%)]和Olive尾距[2.30(0.82,4.77)μm]均明显高于正常组[2.57(1.17,9.34)μg/g、1.70(0.94,2.89)μg/g、6.75%(2.55%,12.60%)、1.25(0.43,2.34)μm],差异均有统计学意义(P<0.05)。logistic回归分析显示,性别、工龄、工种、尾部DNA百分含量、Olive尾距和1-羟基芘均是炭素接触工人肺功能损伤的影响因素(P<0.05)。结论外周血淋巴细胞彗星尾部DNA百分含量、Olive尾距和1-羟基芘含量可能是炭素行业接触工人肺功能损伤的标志物,工龄、工种是影响肺功能损伤的职业因素,应加强工人的职业性防护,制定合理作业制度,保障工人健康。
Objective To investigate the influential factors of lung function injury in occupational exposure workers in carbon industry.MethodsIn January 2024,a judgment sampling method was employed,with 230 occupational exposure workers in the carbon industry as the study subjects.They were divided into abnormal group and normal group according to whether there was lung function injury in occupational health examination.The basic information of workers in carbon industry was collected by questionnaire,their lung function was measured,urine and blood samples were collected after work,and 1-hydroxypyrene,1-hydroxynaphthalene and 2-hydroxynaphthalene concentrations and the percentage of DNA in the comet tail and Olive tail distance in peripheral blood lymphocytes were determined.The differences in indicators of lung function,urine and blood samples between the two groups were compared by Mann-Whitney test and t-test.The influencing factors of lung function injury were analyzed by logistic regression.ResultsThe forced vital capacity(FVC)%[88%(86%,92%)],forced expiratory volume in the first second(FEV 1)%[92%(88%,95%)]and FEV 1.0/FVC%[96%(91%,102%)]of occupational exposure workers in the carbon industry in the normal lung function group(n=118)were significantly higher than those in the abnormal lung function group[n=112,83%(80%,87%),84%(80%,88%),86%(79%,91%)],the differences were statistically significant(P<0.05).1-Hydroxypyrene[9.28(2.96,25.94)μg/g],1-hydroxynaphthalene[2.48(1.47,4.37)μg/g],percentage of DNA in the comet tail[11.83%(5.30%,21.45%)]and Olive tail distance[2.30(0.82,4.77)μm]in the abnormal lung function workers was significantly higher than those in the normal group[2.57(1.17,9.34)μg/g,1.70(0.94,2.89)μg/g,6.75%(2.55%,12.60%),1.25(0.43,2.34)μm],and the differences were statistically significant(P<0.05).Logistic regression analysis showed that sex,working age,job type,percentage of comet tail DNA in peripheral blood,Olive tail distance and 1-hydroxypyrene were all factors influencing lung function injury in occupational exposure workers in carbon industry(P<0.05).ConclusionThe percentage of DNA in the comet tail,Olive tail distance in peripheral blood lymphocytes and 1-hydroxypyrene may be markers of lung function injury in workers exposed to carbon industry.Working age and job type are occupational factors affecting lung function injury.Occupational protection should be strengthened and a reasonable operating system should be established to ensure the health of occupational workers.
作者
孙晓晨
邵华
李宁
韩鹏
王韬
宋丰江
苏东红
崔峰
Sun Xiaochen;Shao Hua;Li Ning;Han Peng;Wang Tao;Song Fengjiang;Su Donghong;Cui Feng(Institute of Occupational Health and Poison Control,Zibo Center for Disease Control and Prevention,Zibo 255026,China;Leadership Office of Shandong Academy of Occupational Health and Occupational Medicine,Jinan 250062,China)
出处
《中华劳动卫生职业病杂志》
北大核心
2025年第3期224-227,共4页
Chinese Journal of Industrial Hygiene and Occupational Diseases
基金
淄博市医药卫生科技项目青年项目(20241701100)。
关键词
肺损伤
炭素
肺功能
代谢产物
影响因素
Lung injury
Carbon
Lung function
Metabolite
Influencing factor
