摘要
On 9 October 2024,in a high-profile vote of confidence for the promise of using artificial intelligence(AI)in scientific discovery,the Royal Swedish Academy of Sciences awarded Demis Hassabis(co-founder and chief executive officer)and John M.Jumper(direc-tor)of Google DeepMind(London,UK)the 2024 Nobel Prize in Chemistry for their pioneering work in developing the AI-powered protein structure prediction model AlphaFold2(AF2)[1].Also shar-ing the prize was David Baker(half to Hassabis and Jumper;half to Baker),professor of biochemistry at the University of Washington(Seattle,WA,USA),for his work on computational protein design that started with the mid-1990s development of Rosetta,a since-evolving suite of software tools that model protein structures using physical principles[2]-and now also AI[3].