摘要
探讨达格列净联合二甲双胍应用于2型糖尿病(T2DM)并发冠心病(CHD)患者的治疗效果。选取贵阳市云岩区人民医院2023年2月―2024年9月收治的接受降糖治疗的60例T2DM并发CHD患者作为研究对象,采用信封法分为对照组和研究组,每组各30例。对照组在常规治疗基础上加用二甲双胍,研究组在常规治疗基础上加用达格列净联合二甲双胍,观察两组血糖控制效果和血脂改善效果。研究结果显示,用药后,研究组的FBG和HbA1c水平下降幅度显著高于对照组(P<0.05);用药后,研究组的TG和LDL-C水平降低幅度显著大于对照组(P<0.05)。研究发现,达格列净联合二甲双胍治疗T2DM并发CHD患者的效果显著,不仅能有效控制血糖,还能实现良好的降脂效果,为临床医生给T2DM并发CHD患者制订用药方案提供了可靠参考。
To explore the therapeutic effect of dapagliflozin combined with metformin in patients with type 2 diabetes mellitus(T2DM)complicated with coronary heart disease(CHD).Sixty patients with T2DM complicated with CHD who received hypoglycemic treatment in Yunyan District People's Hospital from February 2023 to September 2024 were selected as the research objects and divided into a control group and a study group by the envelope method,with 30 cases in each group.The control group was treated with metformin on the basis of conventional treatment,and the study group was treated with dapagliflozin combined with metformin on the basis of conventional treatment.The blood glucose control effect and blood lipid improvement effect of the two groups were observed.The research results showed that after medication,the decrease ranges of fasting blood glucose(FBG)and glycosylated hemoglobin(HbA1c)levels in the study group were significantly higher than those in the control group(P<0.05).After medication,the decrease ranges of triglyceride(TG)and low-density lipoprotein cholesterol(LDL-C)levels in the study group were significantly higher than those in the control group(P<0.05).The study found that the combination of dapagliflozin and metformin has a significant therapeutic effect on patients with T2DM complicated with CHD.It can not only effectively control blood glucose but also achieve a good lipid-lowering effect,providing a reliable reference for clinicians to formulate medication regimens for patients with T2DM complicated with CHD.
作者
姚雪莎
Yao Xuesha(Yunyan District People's Hospital,Guiyang,Guizhou 550001)
关键词
2型糖尿病
冠心病
达格列净
二甲双胍
血糖水平
type 2 diabetes mellitus
coronary heart disease
dapagliflozin
metformin
blood glucose level
