摘要
目的 探讨电视胸腔镜手术(VATS)对非小细胞肺癌(NSCLC)患者免疫功能及内皮损伤指标的影响。方法 将102例NSCLC患者,按照手术方法的不同分为开胸手术(TOS)组(n=50,实施TOS术式)、VATS组(n=52,实施VATS术式)。比较两组患者临床指标、免疫功能指标、内皮损伤指标[内皮素-1(ET-1)、一氧化氮(NO)]和并发症发生情况。结果 VATS组患者出血量明显少于TOS组,住院时间明显短于TOS组,差异均有统计学意义(P﹤0.01)。术后7天,两组患者CD3^(+)、CD4^(+)水平均较术前降低,CD8^(+)水平均较术前升高,且VATS组患者CD3^(+)、CD4^(+)水平均高于TOS组,CD8^(+)水平低于TOS组,差异均有统计学意义(P﹤0.05)。术后7天,两组患者ET-1水平均较术前降低,NO水平均较术前升高,且VATS组患者ET-1水平低于TOS组,NO水平高于TOS组,差异均有统计学意义(P﹤0.05)。VATS组患者并发症总发生率低于TOS组,差异有统计学意义(P﹤0.05)。结论 VATS应用于NSCLC患者中,对机体免疫功能影响更小,可改善血管内皮功能,降低并发症发生风险,促进恢复。
Objective To investigate the effect of video-assisted thoracic surgery(VATS)on immune function and endothelial injury indicators in patients with non-small cell lung cancer(NSCLC).Method A total of 102 patients with NSCLC were divided into thoracotomy(TOS)group(n=50,TOS)and VATS group(n=52,VATS)according to the different surgical methods.The clinical indicators,immune function indicators,endothelial injury indicators[endothelin-1(ET-1),nitric oxide(NO)]and complications were compared between the two groups.Result The blood loss in VATS group was significantly less than that in TOS group,and the length of hospital stay was significantly shorter than that in TOS group,and the differences were statistically significant(P<0.01).At 7 days after operation,the levels of CD3^(+)and CD4^(+)in both groups were lower than those before operation,and the levels of CD8^(+)were higher than those before operation,and the levels of CD3^(+)and CD4^(+)in the VATS group were higher than those in the TOS group,and the level of CD8^(+)was lower than that in the TOS group,and the differences were statistically significant(P<0.05).At 7 days after operation,the levels of ET-1 in the two groups were lower than those before operation,and the levels of NO were higher than those before operation,and the level of ET-1 in the VATS group was lower than that in the TOS group,and the level of NO was higher than that in the TOS group,and the differences were statistically significant(P<0.05).The total incidence of complications in VATS group was lower than that in TOS group,and the difference was statistically significant(P<0.05).Conclusion VATS in NSCLC patients has less influence on immune function,can improve vascular endothelial function,reduce the risk of complications,and promote recovery.
作者
张光耀
王跃斌
方泽民
ZHANG Guangyao;WANG Yuebin;FANG Zemin(Department of Thoracic Surgery,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,He’nan,China;Institute of Lung Cancer Diagnosis and Treatment,Zhengzhou University,Zhengzhou 450000,He’nan,China)
出处
《癌症进展》
2025年第3期273-276,共4页
Oncology Progress
关键词
非小细胞肺癌
开胸手术
电视胸腔镜手术
免疫功能
内皮损伤
non-small cell lung cancer
thoracotomy
video-assisted thoracic surgery
immune function
endothelial injury
