摘要
The dynamic kinetic resolution(DKR)process remains a highly efficacious approach for constructing chiral amino alcohols via the catalytic asymmetric hydrogenation ofα-amino ketones.We report herein a highly efficient and enantioselective anti-selective dynamic kinetic asymmetric hydrogenation ofα-amino ketones catalyzed by Ir-(S)-f-phamidol system,providing various chiral amino alcohols and chiral oxazolidin-2-ones divergently with high diastereo-and enantioselectivity(up to 99%yield,up to 99%ee and up to 99:1 dr).In addition,the reaction could be performed on the gram-scale,and the resulting chiral amino alcohols are key intermediates of norephedrine and metaraminol.
基金
the National Key R&D Program of China(No.2021YFA1500201)
Shenzhen Science and Technology Innovation Committee(No.KQTD20150717103157174)
Stable Support Plan Program of Shenzhen Natural Science Fund(No.20200925161222002)
Key-Area Research and Development Program of Guangdong Province(No.2020B010188001)
Innovative Team of Universities in Guangdong Province(No.2020KCXTD016)
National Natural Science Foundation of China(No.21991113)
the National Natural Science Foundation of China(Nos.21901107 and 22171129)
the Guangdong Basic and Applied Basic Research Foundation(2022B1515020055)
Shenzhen Science and Technology Innovation Committee(No.JCYJ20210324104202007)for financial support。
