摘要
目的探讨盐酸奥普力农在高龄急性失代偿性心力衰竭患者中的临床应用价值。方法选取2022年1—12月新余市人民医院收治的60例高龄急性失代偿性心力衰竭患者作为研究对象,按照随机数字表法分为常规治疗组与奥普力农组,每组30例。常规治疗组给予米力农注射液治疗,奥普力农组给予盐酸奥普力农治疗。比较两组临床症状改善情况、心功能改善情况、心脏功能参数(左心室射血分数、左心室收缩末期内径、左心室舒张末期内径、左心室收缩末期容积、左心室舒张末期容积)、生命体征(心率、收缩压、舒张压)和N末端B型脑钠肽原(Nterminal pro-B-type natriuretic peptide,NT-proBNP)、血尿素氮、血肌酐、血小板计数、WBC水平及不良事件发生情况。结果奥普力农组临床症状改善总有效率为93.33%,高于常规治疗组的70.00%,差异有统计学意义(P<0.05)。奥普力农组心功能改善总有效率为96.67%,高于常规治疗组的73.33%,差异有统计学意义(P<0.05)。治疗后,两组心率均慢于治疗前,NT-proBNP水平均低于治疗前,奥普力农组左心室射血分数高于治疗前与常规治疗组,左心室收缩末期内径、左心室舒张末期内径均短于治疗前与常规治疗组,左心室收缩末期容积、左心室舒张末期容积均小于治疗前与常规治疗组,NT-proBNP水平低于常规治疗组,差异有统计学意义(P<0.05)。治疗前后,两组组内组间血尿素氮、血肌酐、血小板计数、WBC水平比较差异无统计学意义。结论盐酸奥普力农可显著改善高龄急性失代偿性心力衰竭患者的左心室收缩及舒张功能,降低NTproBNP水平,且未增加短期不良反应发生风险,具有较高的临床应用价值。
Objective To explore the clinical application value of olprinone hydrochloride in elderly patients with acute decompensated heart failure.Methods 60 elderly patients with acute decompensated heart failure admitted to Xinyu People's Hospital from January to December 2022 were selected as the research subjects,they were divided into the routine treatment group and the olprinone group according to the random number table method,with 30 cases in each group.The routine treatment group was treated with milrinone injection,and the olprinone group was treated with olprinone.The improvement of clinical symptoms and cardiac function,cardiac function parameters(left ventricular ejection fraction,left ventricular endsystolic diameter,left ventricular enddiastolic diameter,left ventricular endsystolic volume,left ventricular enddiastolic volume),vital signs(heart rate,systolic blood pressure,diastolic blood pressure)and N-terminal pro-B-type natriuretic peptide(NT-proBNP),blood urea nitrogen,serum creatinine,platelet count,WBC levels and adverse events were compared between the two groups.Results The total effective rate of clinical symptom improvement in the olprinone group was 93.33%,which was higher than 70.00%in the routine treatment group,and the difference was statistically significant(P<0.05).The total effective rate of cardiac function improvement in the olprinone group was 96.67%,which was higher than 73.33%in the routine treatment group,and the difference was statistically significant(P<0.05).After treatment,the heart rate of the two groups was slower than that before treatment,the level of NT-proBNP was lower than that before treatment,the left ventricular ejection fraction in the olprinone group was higher than that before treatment and the routine treatment group,the left ventricular end-systolic diameter and left ventricular enddiastolic diameter were shorter than those before treatment and the routine treatment group,the left ventricular endsystolic volume and left ventricular enddiastolic volume were smaller than those before treatment and the routine treatment group,the level of NT-proBNP was lower than that in the routine treatment group,the differences were statistically significant(P<0.05).Before and after treatment,there was no significant difference in blood urea nitrogen,serum creatinine,platelet count and WBC level between the two groups within the groups and between the groups.There were no significant differences in the incidence of arrhythmia and rehospitalization rate of heart failure between the two groups.Conclusion Oplinon hydrochloride significantly improved left ventricular systolic and diastolic function and reduced NT-proBNP levels in elderly patients with acute decompensated heart failure without increasing the risk of short-term adverse effects.
作者
胡小武
曾庆宏
夏金兰
李凯
刘文霞
HU Xiaowu;ZENG Qinghong;XIA Jinlan;LI Kai;LIU Wenxia(Department of Cardiovascular Medicine,Unit 2,Xinyu People's Hospital,Xinyu,Jiangxi,338000,China)
出处
《当代医学》
2024年第36期17-20,共4页
Contemporary Medicine
基金
新余市科技计划项目(20223090876)。
关键词
盐酸奥普力农
左心室射血分数
心功能
急性失代偿性心力衰竭
Oprinone hydrochloride
Left ventricular ejection fraction
Cardiac function
Acute decompensated heart failure
