摘要
Cardiovascular disease(CVD)remains a major cause of death and rising health care costs worldwide[1].Hyperlipidemia is an important,modifiable risk factor for CVD[2].Consequently,prevention and treatment of CVD have emphasized targeting low-density lipoprotein cholesterol(LDL-C)[3].However,despite the efficiency of statins to reduce LDL-C concentration,the risk of recurrent cardiovascular events and mortality remains[4].Systemic inflammation has emerged as an important source of residual cardiovascular risk among patients receiving statin therapy[4].These contemporary data support the use of inflammation-inhibiting interventions as an effective strategy to further reduce cardiovascular risk.Diet is a highly modifiable lifestyle factor that has been shown to play a role in the regulation of systemic inflammation[5].Previous studies revealed that a higher dietary inflammatory potential was associated with an increased incidence of CVD and mortality in the general population[6].However,it is unclear whether this association persists in patients at-risk of or with established CVD who are already being treated with statins,a therapy whose mode of action includes decreasing inflammation[7].Evaluating the potential for residual risk due to diet is critical considering the large role inflammation plays in cardiovascular diseases.
基金
National Natural Science Foundation of China(82311530048 and 82371298)
Capital Health Research and Development of Special Fund(2024-2-2086)
Talent Development Program of Beijing Shijitan Hospital(2024LJRCLS).
