摘要
食管癌是一种预后较差的恶性肿瘤。目前,食管癌患者的治疗手段包括手术治疗、化学治疗、放射治疗等,但存在术后恢复较差、肿瘤易转移、易产生化学治疗药物耐药性和放射治疗抵抗性等问题。沉默信息调节因子(silence information regulator,SIRT)1与多种细胞生物学过程相关,例如DNA修复、细胞衰老、线粒体稳态等。SIRT1是目前研究最为广泛的SIRT家族成员。既往研究表明SIRT1与人类肿瘤的发生和发展存在密切联系。文章表明,SIRT1通过促进食管癌细胞增殖,促进食管癌细胞转移,诱导食管癌细胞自噬等方面促进食管癌的发生和发展。抑制SIRT1的表达,临床上可能具有抑制食管癌发生和发展的作用,这可能为临床治疗食管癌提供一些思路。
Esophageal cancer is a malignant tumor with a poor prognosis.Current treatment options for esophageal cancer include surgery,chemotherapy,and radiotherapy;however,these approaches are often associated with poor postoperative recovery,high metastatic potential,and the development of drug resistance to chemotherapeutic drugs and radiotherapy.Silence information regulator(SIRT)1 is involved in various cellular biological processes such as DNA repair,cellular senescence,and mitochondrial homeostasis.SIRT1 is the most extensively studied member of the SIRT family.Previous studies have shown that SIRT1 is closely related to the initiation and progression of human cancers.The studies have showed that SIRT 1 promoted the occurrence and development of esophageal cancer by promoting the proliferation of esophageal cancer cells,promoting the metastasis of esophageal cancer cells,and inducing autophagy of esophageal cancer cells.Inhibition of the expression of SIRT 1 may have the effect of inhibiting the occurrence and development of esophageal cancer in clinical practice,which may provide some ideas for the clinical treatment of esophageal cancer.
作者
石晓丽
王成香
付金妮
闫麒麟
蔺成英
马霖
SHI Xiaoli;WANG Chengxiang;FU Jinni;YAN Qilin;LIN Chengying;MA Lin(Department of Pharmacy,Affiliated Hospital of Qingdao University,Qingdao Shandong 266000)
出处
《临床与病理杂志》
2024年第11期1589-1596,共8页
Journal of Clinical and Pathological Research
关键词
沉默信息调节因子1
食管癌
化学治疗
放射治疗
耐药性
细胞自噬
silence information regulation 1
esophageal cancer
chemotherapy
radiotherapy
drug resistance
autophagy
