摘要
海参多肽因其独特的结构和多样的生物活性,在神经系统疾病的治疗潜力方面引起广泛关注。研究表明,海参多肽具有抗氧化、抗炎和免疫调节等生物活性,可有效减轻神经炎症及氧化应激对神经细胞的损伤,进而保护神经元。近年来,海参多肽在阿尔茨海默病、帕金森病及脑卒中等神经系统疾病中的作用机制成为研究热点。研究结果显示,海参多肽可通过抑制炎症反应、调节神经递质水平和促进神经再生等途径对神经退行性病变产生积极影响。然而,目前相关研究多集中于体外和动物实验阶段,临床研究证据相对不足,仍需进一步探索其安全性和有效性。文章综述了海参多肽的主要生物活性及其在神经系统疾病应用的最新进展,为其后续研究和临床应用提供参考。
Sea cucumber polypeptides have garnered significant attention in the treatment of neurological diseases due to their unique structure and diverse biological activities.Recent studies have shown that sea cucumber polypeptides possess biological activities such as antioxidant,anti-inflammatory,and immune modulation,effectively reducing neural inflammation and oxidative stress on nerve cells,thereby protecting neurons.Specifically,the mechanisms by which sea cucumber polypeptides act in neurological diseases,including Alzheimer’sdisease,Parkinson’sdisease,and stroke,have become focal points of research in recent years.These polypeptides can positively impact neurodegenerative changes by suppressing inflammatory responses,modulating neurotransmitter levels,and promoting neuroregeneration.Despite promising findings,current studies are mainly focused on in vitro and animal experiments,with relatively limited clinical research evidence;thus,further exploration of their safety and efficacy is required.This paper reviews the primary biological activities of sea cucumber polypeptides and their recent advancements in applications to neurological diseases,providing references for future research and clinical application.
作者
龚正
余华军
张海涛
GONG Zheng;YU Huajun;ZHANG Haitao(Department of Biochemistry and Molecular Biology,Guangdong Medical University,Zhanjiang 524023,China;Experimental Animal Center of Guangdong Medical University,Zhanjiang 524023,China)
出处
《新医学》
2025年第3期243-250,共8页
Journal of New Medicine
基金
广东省基础与应用基础研究基金(2024A1515013157)
广东省中医药局科研项目(20231225)。
关键词
海参多肽
生物活性
神经保护
抗氧化
神经系统疾病
Sea cucumber polypeptides
Biological activity
Neuroprotection
Antioxidant
Neurological diseases
