摘要
目的:探讨中性粒细胞/淋巴细胞比值(NLR)、单核细胞/淋巴细胞比值(MLR)、血小板/淋巴细胞比值(PLR)及相关炎性指标与脓毒症不良预后的相关性。方法:选取新疆生产建设兵团医院重症医学科2020年1月至2022年12月期间收治的200例脓毒症患者作为观察对象,借助医院病案系统进行在线查询,应用Epidata软件从系统中采集入组患者的各项临床资料,查询患者治疗28 d内的临床转归情况,按照转归结果将患者分为生存组和死亡组。比较两组患者NLR、MLR、PLR及相关炎性指标的差异,采用logistic回归分析脓毒症患者的影响因素。结果:生存组的NLR与尿素氮(BUN)水平低于死亡组,差异有统计学意义(P <0.05),白蛋白(ALB)水平高于死亡组,差异有统计学意义(P<0.05)。经二元logistic回归分析,NLR是脓毒症患者死亡的独立危险因素(P<0.05)。NLR在脓毒症预后具有良好的预测效能(AUC=0.705,95%CI 0.525~0.891,P=0.037)。结论:NLR是脓毒症患者死亡的独立危险因素,应持续监测脓毒症患者NLR、PLR、MLR及相关炎性指标水平,为脓毒症患者的预后预测提供依据。
Objective To explore the correlation between neutrophil to lymphocyte ratio(NLR),monocyte to lymphocyte ratio(MLR),platelet to lymphocyte ratio(PLR),and related inflammatory indicators and poor prognosis in sepsis.Methods 200 sepsis patients admitted to our ICU from January 2020 to December 2022 were collected as observation subjects.The hospital's medical record system was used for online queries,and Epidata software was used to collect various clinical data of the enrolled patients from the system.The clinical outcomes of the patients within 28 days of treatment were queried,and the patients were divided into survival group and death group according to the prognosis effect.The differences in the neutrophilto-lymphocyte ratio(NLR),monocyte-to-lymphocyte ratio(MLR),platelet-to-lymphocyte ratio(PLR),and other related inflammatory indicators between the two patient groups were compared.Additionally,logistic regression was employed to analyze the factors influencing sepsis in these patients.Results The NLR and blood urea nitrogen(BUN)levels in the survival group were significantly lower than those in the death group(P<0.05).Conversely,the albumin(ALB)levels in the survival group were significantly higher than those in the death group(P<0.05).Following binary logistic regression analysis,the Neutrophil-to-Lymphocyte Ratio(NLR)was identified as an independent risk factor for mortality in patients with sepsis(P<0.05).Furthermore,NLR demonstrated strong predictive performance for sepsis prognosis,with an Area Under the Curve(AUC)of 0.705 and a 95%Confidence Interval(CI)ranging from 0.525 to 0.891(P=0.037).Conclusion In terms of the severity and prognosis analysis of sepsis,clinical testing and analysis of NLR,PLR,MLR,and related inflammatory indicators can be actively conducted.NLR is an independent risk factor for the prognosis and mortality of sepsis patients.
作者
苑晓姣
刘燕
刘倩
YUAN Xiaojiao;LIU Yan;LIU Qian(ICU,Hospital of Xinjiang Production and Construction Crops,Urumqi,Xinjiang,830002)
出处
《兵团医学》
2024年第4期29-32,共4页
Journal of BingTuan Medicine
