摘要
目的探讨山西省2018至2021年结缔组织病(CTD)合并肺高血压患者的流行病学特征。方法该研究为横断面调查。筛选2018至2021年山西省卫生健康统计直报系统中的CTD合并肺高血压患者, 筛选依据为住院患者病案首页提供的信息。收集入选患者的相关临床资料, 分析、总结不同类型CTD合并肺高血压患者的流行病学特征。不同年份的山西省总人口数从山西省统计年鉴中获取。结果共纳入CTD合并肺高血压患者1 697例, 其中干燥综合征(SS)患者451例(26.58%)、系统性红斑狼疮(SLE)患者392例(23.10%)、系统性硬化症(SSc)患者289例(17.03%)、混合性CTD(MCTD)患者109例(6.42%)、大动脉炎患者69例(4.07%)、其他CTD患者387例(22.80%)。1 697例患者中女性占绝大多数[1 410例(83.09%)], 年龄以41~65岁者居多[783例(46.14%)], 行右心导管检查者6例(0.35%)。2018至2021年山西省CTD合并肺高血压的患病率呈逐年上升趋势, 依次为0.06/万人、0.10/万人、0.13/万人和0.20/万人。不同类型CTD合并肺高血压患者肺高血压严重程度、纽约心脏协会(NYHA)心功能分级、住院时间、住院费用及转归差异均有统计学意义(均P<0.001), 其中SSc合并肺高血压患者NYHA心功能Ⅲ/Ⅳ级者占比最高[65.1%(188/289)]、住院时间最长[13(9, 18)d]、住院费用最高[13 622.67(8 636.38, 20 597.75)元]、好转出院率最低[51.90%(150/289)]。结论山西省2018至2021年CTD合并肺高血压患者中女性占比高、41~65岁者占比高, 右心导管检查率较低, 其中CTD以SS多见, 2018至2021年患病率呈逐年上升趋势;不同类型CTD合并肺高血压患者中, SSc患者心功能受损最为严重、住院时间较长、住院费用较高、临床转归较差。
ObjectiveTo investigate the clinical-epidemiological characteristics of connective tissue diseases(CTD)complicated with pulmonary hypertension in Shanxi province from 2018 to 2021.MethodsThis was a cross-sectional study.Data of CTD patients with pulmonary hypertension from 2018 to 2021 were collected from the Shanxi Provincial Health Statistics Direct Reporting System based on inpatient medical records.The demographic and clinical data of patients with different CTD types were analyzed.ResultsA total of 1697 CTD patients with pulmonary hypertension were included,among whom there were 451 cases(26.58%)of Sjögren′s syndrome,392 cases(23.10%)of systemic lupus erythematosus,289 cases(17.03%)of systemic sclerosis,109 cases(6.42%)of mixed CTD,69 cases(4.07%)of Takayasu arteritis,and 387 cases(22.80%)of other CTD.The majority of patients were female(1410(83.09%)),and 783 cases(46.14%)were aged between 41 and 65 years,and 6 cases(0.35%)were performed right heart catheterization.The prevalence of CTD with pulmonary hypertension increased from 0.06/104 in 2018 to 0.20/104 in 2021.There were significant differences in the severity of pulmonary hypertension,New York Heart Association(NYHA)functional class,length of hospital stay,medical costs,and clinical outcomes among patients with different CTD subtypes(all P<0.001).Patients with systemic sclerosis had the highest proportion of NYHA functional classⅢ/Ⅳ(65.1%(188/289)),the longest length of hospital stays(13(9,18)days),the highest average medical costs(13622.67(8636.38,20597.75)¥(RMB)),and the lowest rate of improvement and discharge(51.90%(150/289)).ConclusionsBetween 2018 and 2021,Shanxi province,where CTD is more common in Sjögren′s syndrome,has a high proportion of women,a high proportion of people aged 41-65 years,and a low prevalence of right ventricular catheterization in patients with CTD complicated with pulmonary hypertension.The prevalence of CTD complicated with pulmonary hypertension shows a rising trend in Shanxi province from 2018 to 2021,while patients with systemic sclerosis exhibit the most severe cardiac impairment and poorer clinical outcomes compared to other subtypes.
作者
王莉枝
韩学斌
李俐
王志鑫
郭彦青
Wang Lizhi;Han Xuebin;Li Li;Wang Zhixin;Guo Yanqing(Department of Geriatrics,Shanxi Provincial Cardiovascular Hospital,Taiyuan 030024,China;Department of Cardiology,Shanxi Provincial Cardiovascular Hospital,Taiyuan 030024,China;Laboratory of Shanxi Provincial Cardiovascular Hospital,Taiyuan 030024,China)
出处
《中华全科医师杂志》
2025年第2期156-161,共6页
Chinese Journal of General Practitioners
基金
山西省卫生健康委员会重点专项(2020XM16)。
关键词
高血压
肺性
结缔组织病
流行病学
Hypertension,pulmonary
Connective tissue disease
Epidemiology
