摘要
肠道是动物机体主要的免疫器官之一,肠道炎症常伴随肠黏膜损伤、肠壁通透性增强和腹泻等症状,且肠道炎症可能由细胞焦亡介导。细胞焦亡是由焦孔素(gasdermin)蛋白介导,以细胞膜孔形成、膜破裂、细胞肿胀和细胞内容物释放为主要特征的程序性细胞死亡。当机体肠道受到感染性和非感染性因素的干扰时,过度的细胞焦亡可能会引起肠道炎症,导致一系列疾病的发生。本文系统地总结了细胞焦亡的信号通路及在动物肠道炎症损伤中的作用,以期为后续肠道炎症的治疗提供思路。
The intestine is one of the primary immune organs in animal body.Intestinal inflammation is often accompanied by symptoms such as mucosal damage,increased intestinal wall permeability and diarrhea,and may be mediated by pyroptosis.Pyroptosis is a form of programmed cell death mediated by gasdermin protein and characterized by cell membrane pore formation,membrane rupture,cell swelling and release of cell contents.When the organism,s intestinal tract is disturbed by infectious and non-infectious factors,excessive cellular pyroptosis may cause intestinal inflammation,leading to a variety of diseases.This review summarizes the signaling pathways of pyroptosis and its role in intestinal inflammatory injuries in animals aiming to provide ideas for the treatment of intestinal inflammation.
作者
陈纪薇
王哲奇
高爱琴
徐元庆
CHEN Jiwei;WANG Zheqi;GAO Aiqin;XU Yuanqing(College of Animal Science,Inner Mongolia Agricultural University,Hohhot 010018,China;Institute of Grassland Research of Chinese Academy of Agricultural Sciences,Hohhot 010010,China)
出处
《动物营养学报》
北大核心
2025年第3期1480-1488,共9页
CHINESE JOURNAL OF ANIMAL NUTRITION
基金
内蒙古自治区自然科学基金(2022QN03005,2023LHMS03064)
内蒙古自治区直属高校基本科研业务费项目(BR220135,BR22-13-13)
内蒙古农业大学动物科学学院高水平成果培育专项(QT202214)。
