摘要
目的 研究帕罗西汀联合情绪释放疗法治疗伴焦虑症状的老年抑郁症患者对负性情绪及睡眠质量的影响。方法 2020年6月~2023年3月本院收治112例伴焦虑症状的老年抑郁症患者,随机分为两组,对照组56例给予帕罗西汀片治疗,观察组56例采用帕罗西汀联合情绪释放疗法治疗。比较两组匹兹堡睡眠质量指数(Pittsburgh Sleep Quality Index,PSQI)评分、汉密尔顿焦虑量表(Hamilton anxiety rating scale,HAMA)评分、汉密尔顿抑郁量表(Hamilton depression rating scale,HAMD)评分、健康调查量表(Short form-36 health survey,SF-36)评分,检测血清5-羟色胺(5-hydroxytryptamine,5-HT)、去甲肾上腺素(Norepinephrine,NE)、多巴胺(Dopamine,DA)水平。结果 干预后两组PSQI关于睡眠质量、障碍、效率、时间四方面得分均降低(P<0.05);干预后观察组PSQI关于睡眠质量、障碍、效率、时间四方面得分低于对照组(P<0.05);干预后,两组HAMA评分、HAMD评分有所降低且观察组低于对照组(P<0.05);干预后,两组SF-36各项评分有所提高且观察组高于对照组(P<0.05);两组干预后血清5-HT、NE、DA水平有所提高(P<0.05);两组干预后血清5-HT、NE、DA水平无明显差异(P>0.05)。结论 帕罗西汀联合情绪释放疗法治疗伴焦虑症状的老年抑郁症患者有利于减轻焦虑、抑郁等负性情绪,改善患者的睡眠质量,可能与调节5-HT等神经递质有关。
Objective To study the effects of paroxetine combined with emotion release therapy on negative emotions and sleep quality in elderly depression patients with anxiety symptoms.Methods From June 2020 to March 2023,112 elderly depression patients with anxiety symptoms were admitted to our hospital and randomly divided into two groups.The control group(56 cases)was treated with paroxetine tablets,while the observation group(56 cases)was treated with paroxetine combined with emotion release therapy.The score of Pittsburgh Sleep Quality Index(PSQI),Hamilton anxiety rating scale(HAMA),Hamilton depression rating scale(HAMD)and short form-36 health survey(SF-36)were compared between the two groups.Results After intervention,the scores of PSQI on sleep quality,disturbance,efficiency and time were decreased in both groups(P<0.05).After intervention,PSQI scores of sleep quality,disturbance,efficiency and time in the observation group were lower than those in the control group(P<0.05),and the serum levels of 5-hydroxytryptamine(5-HT),Norepinephrine(NE)and Dopamine(DA)were detected.After treatment,HAMA scores and HAMD scores of the two groups were decreased,and the observation group was lower than the control group(P<0.05).After treatment,the scores of SF-36 in both groups were improved,and the observation group was higher than the control group(P<0.05).The levels of serum 5-HT,NE and DA in 2 groups were in-creased after intervention(P<0.05). There were no significant differences in serum 5-HT,NE and DA levels betweenthe two groups after intervention(P>0.05). Conclusion The combination of paroxetine and emotion release therapyis beneficial for reducing negative emotions such as anxiety and depression in elderly depression patients with anxietysymptoms,improving their sleep quality,and may be related to regulating neurotransmitters such as 5-HT.
作者
齐健
杨路静
樊倩
QI Jian;YANG Lujing;FAN Qian(Beijing Friendship Hospital Affiliated to Capital Medical University,Beijing 100050,China)
出处
《国际精神病学杂志》
2025年第1期110-113,135,共5页
Journal Of International Psychiatry
基金
河北省医学科学研究课题计划(编号:20231766)。
关键词
抑郁
情绪释放疗法
负性情绪
焦虑症状
Depression
Emotional release therapy
Negative emotions
Anxiety symptoms
