摘要
目的:观察针烙法对虚寒瘀阻型白癜风的影响。方法:将62例虚寒瘀阻型白癜风患者随机分为观察组和对照组,每组31例。在308 nm准分子光照射联合改良中药热溻法治疗基础上,对照组给予他克莫司软膏外用治疗,每日2次;观察组予针烙法治疗,以火针点刺白斑处,每周1次。均治疗10周。观察两组患者治疗前后白斑面积、中医证候积分、血清炎性指标[白细胞介素(IL)-6、IL-17]含量,并评定两组临床疗效。结果:治疗后,两组患者白斑面积、中医证候积分及血清IL-6、IL-17含量较治疗前降低(P<0.05),且观察组低于对照组(P<0.05)。观察组总有效率为93.5%(29/31),高于对照组的77.4%(24/31,P<0.05)。结论:针烙法可缩小虚寒瘀阻型白癜风患者白斑面积,改善临床症状,可能与降低血清炎性指标水平有关。
Objective To observe the clinical effect of needle cauterization on vitiligo with deficiency cold and blood stasis.Methods A total of 62 patients of vitiligo with deficiency cold and blood stasis were randomly divided into an observation group and a control group,31 cases each group.On the basis of 308 nm excimer light irradiation combined with ironing with Chinese medicine,the control group was treated with tacrolimus ointment for external use,twice a day;the observation group was treated with needle cauterization at vitiligo spots,once a week.Both groups were treated for 10 weeks.Before and after treatment,the area of vitiligo spot,TCM syndrome score,serum levels of inflammatory indexes(interleukin[IL]-6 and IL-17)were observed in the two groups,and the clinical effect was evaluated.Results After treatment,the areas of vitiligo spot,TCM syndrome scores and serum levels of IL-6,IL-17 were decreased compared with those before treatment in both groups(P<0.05),and the above indexes in the observation group were lower than those in the control group(P<0.05).The total effective rate in the observation group was 93.5%(29/31),which was higher than 77.4%(24/31)in the control group(P<0.05).Conclusion Needle cauterization could reduce the areas of vitiligo spot in patients of vitiligo with deficiency cold and blood stasis,improve the clinical symptoms,its mechanism may be related to the reduction of serum levels of inflammatory indexes.
作者
杜红红
刘湘
吴贝贝
李彤彤
刘楠
DU Honghong;LIU Xiang;WU Beibei;LI Tongtong;LIU Nan(Department of Dermatology,Hebei Hospital of TCM,Shijiazhuang 050011,China)
出处
《中国针灸》
北大核心
2025年第3期327-330,共4页
Chinese Acupuncture & Moxibustion
基金
河北省中医药管理局科研计划项目:2021006。
关键词
白癜风
虚寒瘀阻型
针烙法
中药热溻法
308
nm准分子光照射
随机对照试验
vitiligo,deficiency cold and blood stasis
needle cauterization
ironing with Chinese medicine
308 nm excimer light irradiation
randomized controlled trial(RCT)
