摘要
类风湿关节炎(RA)是一种复杂的自身免疫性疾病,细胞焦亡的过度激活导致的免疫微环境失调是疾病进展的关键因素。基于中医营卫理论,认为“营衰卫伐”是RA的发病基础,细胞焦亡是“营衰卫伐”的微观体现,“营衰卫伐”可能与细胞焦亡及RA免疫微环境失调存在着潜在的关联。基于“营衰卫伐”提出RA的治疗原则,即疾病早期益卫固表、调营散邪,疾病中后期和营通滞、滋其化源。
As a complex autoimmune disease,rheumatoid arthritis(RA)involves immune microenvironment dysregulation resulting from excessive activation of pyroptosis,which is a crucial factor in disease progression.Based on the theory of ying-wei in traditional Chinese medicine,"ying decline and wei attack"is considered the fundamental pathogenesis of RA.Pyroptosis serves as a microscopic manifestation of this concept,suggesting a potential correlation between"ying decline and wei attack"and pyroptosis nd immune microenvironment dysregulation in RA.Accordingly,treatment principles based on this theory are proposed:in the early stage of the disease,boosting wei to consolidate the exterior,and regulating ying to dispel pathogens;in the middle and late stages,harmonizing ying to remove stagnation,and nourishing its transformational source.
作者
李燕村
朱姝
王钰涵
渠源
刘源
姜萍
LI Yancun;ZHU Shu;WANG Yuhan;QU Yuan;LIU Yuan;JIANG Ping(Shandong University of Traditional Chinese Medicine,Jinan,250355)
出处
《中医杂志》
北大核心
2025年第5期464-467,491,共5页
Journal of Traditional Chinese Medicine
基金
国家自然科学基金(82274481)
山东省自然科学基金(ZR2023QH006)
山东省研究生教育教学改革项目(SDYAL2023048)。
关键词
类风湿关节炎
细胞焦亡
免疫微环境
营衰卫伐
rheumatoid arthritis
pyroptosis
immune microenvironment
ying decline and wei attack
