摘要
脑膜炎败血伊丽莎白菌(Elizabethkingia meningoseptica,EM)可引起脑膜炎、败血症、肺部感染、眼部感染、导管相关血流感染和手术部位感染,是医院内感染的重要病原菌之一。EM的感染机制包括侵入宿主细胞、产蛋白酶、生物膜等,EM可产生相关毒力因子使免疫系统受损。此外,EM携带多个耐药基因对临床常用抗菌药物具有耐药性。本文通过对EM的感染类型、临床特征及感染机制等方面进行综述,旨在为EM感染的检测和治疗提供参考。
Elizabethkingia meningoseptica(EM)can cause meningitis,sepsis,lung infection,eye infection,catheter-related bloodstream infection and surgical site infection.EM is one of the important pathogens of nosocomial infection.The infection mechanisms of EM include invasion of host cells,production of proteases,biofilms,etc,and EM can produce related virulence factors to damage the immune system.In addition,EM carries multiple drug resistance genes and is resistant to commonly used antibiotics in clinical practice.This article reviews the infection types,clinical features and infection mechanisms of EM,which would provide a reference for the diagnosis and clinical treatment of EM infection.
作者
王雨彤
王馨瑜
林诺
方波
张可盈
孙桂芹
WANG Yutong;WANG Xinyu;LIN Nuo;FANG Bo;ZHANG Keying;SUN Guiqin(School of Medical Technology and Information Engineering,Zhejiang Chinese Medical University,Hangzhou 310053,Zhejiang Province,China)
出处
《微生物与感染》
2024年第5期314-320,共7页
Journal of Microbes and Infections
关键词
脑膜炎败血伊丽莎白菌
感染
临床特征
感染机制
Elizabethkingia meningoseptica
Infection
Clinical characteristic
Infection mechanism
