摘要
心力衰竭是各种心脏结构或功能性疾病导致心室充盈和(或)射血功能受损,心排血量不能满足机体代谢需要的一种综合征,目前心力衰竭中心肌细胞损伤的机制尚不明确。心肌细胞的主要能量来自于线粒体,包括产生三磷酸腺苷和参与能量代谢,因此线粒体完整性和功能丧失导致心脏结构和功能的改变。线粒体自噬是一种细胞内针对衰老或损伤线粒体的选择性降解机制,在细胞的线粒体质量控制系统中发挥重要作用。近年来,研究发现线粒体自噬与心血管疾病的发生发展密切相关,包括心肌梗死、心肌缺血/再灌注损伤、糖尿病心肌病、心力衰竭等。文章主要就线粒体自噬在心力衰竭中的研究进展,包括线粒体自噬的定义与分子机制,线粒体自噬在心力衰竭中的作用机制以及潜在的治疗靶点等方面的研究进展进行综述。
Heart failure is a syndrome in which ventricular filling and/or ejection function is impaired due to various cardiac structural or functional diseases,and cardiac output cannot meet the metabolic needs of the body.At present,the mechanism of myocardial cell damage in heart failure is still unclear.Cardiomyocytes derive most of their energy from mitochondria,including the production of ATP and participation in energy metabolism,so loss of mitochondrial integrity and function leads to changes in heart structure and function.Mitophagy is a selective degradation mechanism of aging or damaged mitochondria,which plays an important role in the mitochondrial quality control system of cells.In recent years,studies have found that mitophagy is closely related to the occurrence and development of cardiovascular diseases,including myocardial infarction,myocardial ischemia/reperfusion injury,diabetic cardiomyopathy,heart failure,etc.This article mainly reviews the research progress of mitophagy in heart failure,including the definition and molecular mechanism of mitophagy in heart failure,the mechanism of action and potential therapeutic targets.
作者
戴昕晴
林德健(综述)
徐海霞(审校)
DAI Xinqing;LIN Dejian(revewing);XU Haixia(checking)(Department of Cardiology,Affiliated Hospital of Nantong University,Nantong 226001,Jiangsu,China)
出处
《医学研究与战创伤救治》
北大核心
2025年第2期208-214,共7页
Journal of Medical Research & Combat Trauma Care
基金
国家自然科学基金(82100277)。
