摘要
目的:采用高效液相色谱法(HPLC)同时测定化妆品中23种防腐剂,并对结果进行分析。方法:色谱条件:采用Agilent ZORBAX SB-C_(18)色谱柱(250 mm×4.6 mm,5μm);以0.1%磷酸水溶液、乙腈为流动相,梯度洗脱;流速为1.0 mL/min;柱温为30℃。结果:通过采用HPLC同时测定化妆品(47批)中23种防腐剂,发现3批次样品中防腐剂用量超标,6批次样品未检出23种组分中任何一种组分。结论:该方法可为化妆品中防腐剂的检测提供参考依据,梅州市售化妆品存在一定的质量风险,需加强安全风险管控。
Objective:To determine 23 preservatives in cosmetics by high performance liquid chromatography(HPLC)and analyze the results.Methods:Chromatographic conditions:using Agilent ZORBAX SB-C18 column(250 mm 4.6 mm,5μm);with 0.1%aqueous phosphoric acid,acetonitrile as the mobile phase;flow rate is 1.0 mL/min;column temperature is 30℃.Results:By measuring 23 preservatives in cosmetics(47 batches),the number of preservatives in 3 batches of samples exceeded the standard,and no one of 23 components was detected in 6 batches of samples.Conclusion:This method can provide a reference basis for the detection of preservatives in cosmetics.There are certain quality risks for cosmetics sold in Meizhou city,so the safety risk control should be strengthened.
作者
严倩茹
邬伟魁
李艳媚
吴辉
宋增炫
陈媛
朱茂玉
Yan Qianru;Wu Weikui;Li Yanmei;Wu Hui;Song Zengxuan;Chen Yuan;Zhu Maoyu(Meizhou Institute for Food and Drug Control,Meizhou 514071,China;Jieyang Instituted for Drug Control,Jieyang 522000,China)
出处
《广东化工》
2025年第3期138-139,124,共3页
Guangdong Chemical Industry
基金
广东省梅州市社会发展科技计划项目(2022B119)
广东省药监局科技创新项目(2022TDB73)。
关键词
化妆品
防腐剂
质量风险
cosmetics
preservatives
quality risk
