摘要
铁死亡是一种新型的细胞死亡方式,主要由氧化损伤和还原防护失衡引起。作为一种新型的肿瘤治疗手段,诱导细胞铁死亡引起了研究者们的广泛关注。但是现有的小分子铁死亡诱导剂因水溶性低、半衰期短和靶向能力差等缺点,在临床应用中受到极大限制。随着纳米科学的快速发展,纳米技术为触发细胞铁死亡而治疗肿瘤提供了新的可能性。本文主要综述了基于铁死亡的肿瘤纳米疗法及其与化疗、免疫治疗、超声治疗、光热治疗和化学动力学治疗等方法相结合的联合疗法的最新进展,期望为新型肿瘤治疗方法的开发提供参考。
Ferroptosis is a novel mode of cell death,which is mainly caused by an imbalance between oxidative damage and reductive protection.As a novel tumor therapy method,induction of cellular ferroptosis has attracted extensive attention from researchers.However,existing small-molecular ferroptosis inducers are greatly limited in clinical applications due to the drawbacks of low water solubility,short half-life and poor targeting ability.With the rapid development of nanoscience,nanotechnology offers new possibilities to treat tumors by triggering cellular ferroptosis.This paper mainly reviews the recent progress of tumor nano-therapies based on ferroptosis and their combination therapies with chemotherapy,immunotherapy,ultrasound therapy,photothermal therapy,and chemodynamic therapy,expecting to provide a reference for the development of novel tumor therapeutic approaches.
作者
周玥
廖鑫颖
肖紫懿
黄晓之
石芸芸
刘阳
Zhou Yue;Liao Xinying;Xiao Ziyi;Huang Xiaozhi;Shi Yunyun;Liu Yang(Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research,Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study,School of Pharmacology,Hengyang Medical School,University of South China,Hengyang 421001,China)
出处
《广东化工》
2025年第3期73-75,共3页
Guangdong Chemical Industry
基金
湖南省教育厅优秀青年项目(23B0447)
国家级大学生研究性学习和创新性实验计划项目(202210555094)。
关键词
铁死亡
纳米疗法
肿瘤治疗
联合治疗
ferroptosis
nano-therapy
tumor therapy
combination therapy
