摘要
目的:观察阿加曲班联合阿司匹林治疗急性脑梗死(ACI)患者的效果。方法:回顾性分析2021年6月至2023年6月该院收治的76例ACI患者的临床资料,按照治疗方法不同将其分为观察组与对照组各38例。两组均进行基础治疗和阿替普酶静脉溶栓治疗,在此基础上,对照组予以阿司匹林治疗,观察组在对照组基础上联合阿加曲班治疗,两组均连续治疗7 d。比较两组临床疗效,治疗前后神经功能缺损[美国国立卫生研究院卒中量表(NIHSS)]评分、大脑中动脉血流指标[收缩期峰值流速(PSV)、舒张末期峰值流速(EDV)、平均流速(Vm)]水平,以及不良反应发生率。结果:观察组治疗总有效率为94.74%(36/38),高于对照组的76.32%(29/38),差异有统计学意义(P<0.05);治疗后,两组NIHSS评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组EDV、PSV、Vm水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:阿加曲班联合阿司匹林治疗ACI患者可提高治疗总有效率和大脑中动脉血流指标水平,降低神经功能缺损评分,效果优于单纯阿司匹林治疗。
Objective:To observe effects of Argatroban combined with Aspirin in treatment of patients with acute cerebral infarction(ACI).Methods:The clinical data of 76 patients with ACI admitted to this hospital from June 2021 to June 2023 were retrospectively analyzed.According to different treatment methods,they were divided into observation group and control group,38 cases in each group.Both groups were treated with basic treatment and Alteplase intravenous thrombolysis.On this basis,the control group was treated with Aspirin,while the observation group was treated with Argatroban on the basis of that of the control group.Both groups were treated for 7 d.The clinical efficacies,the neurological deficit[National Institutes of Health stroke scale(NIHSS)]scores,the middle cerebral artery blood flow index[peak systolic velocity(PSV),end diastolic peak velocity(EDV),mean velocity(Vm)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 94.74%(36/38),which was higher than 76.32%(29/38)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the NIHSS scores of the two groups were lower than those before the treatment,that in the observation group was lower than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of EDV,PSV and Vm in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Argatroban combined with Aspirin in the treatment of the ACI patients can improve the total effective rate of treatment and the levels of middle cerebral artery blood flow indexes,and reduce the neurological function scores.Moreover,it is superior to simple Aspirin treatment.
作者
王光辉
WANG Guanghui(Department of Neurology of Yanling Hospital,Xuchang 461200 Henan,China)
出处
《中国民康医学》
2025年第6期16-18,共3页
Medical Journal of Chinese People’s Health
关键词
急性脑梗死
阿加曲班
阿司匹林
大脑中动脉
神经功能缺损
不良反应
Acute cerebral infarction
Argatroban
Aspirin
Middle cerebral artery
Neurological deficit
Adverse reaction
