摘要
作为中医领域传统抗癌方剂中的关键组分——黄芩,其药效在现代药理学研究中得到了充分验证,其不仅具有抗肿瘤、镇静安神的作用,还拥有镇痛及抗菌消炎等多重药理活性。值得一提的是,黄芩中的活性成分——黄芩苷,因其良好的抗肿瘤活性,近年来已成为国内外研究的热点。通过查阅相关文献,了解到黄芩苷在抗肝癌、乳腺癌、卵巢癌、胃癌及多种其他类型肿瘤方面均展现出良好的疗效,其机制包括抑制肿瘤细胞增殖和引发肿瘤程序性细胞死亡(programmed cell death,PCD),如凋亡、焦亡以及铁死亡等。PCD作为一种重要的细胞生物学过程,在肿瘤的发生发展中具有广泛的功能和影响,研究黄芩苷引发肿瘤PCD的作用机制对寻找抗肿瘤治疗的靶点具有重要意义。本文就黄芩苷引发肿瘤细胞PCD作用机制的研究进展进行综述,以期为进一步研究其抗肿瘤的作用机制提供分子靶标以及理论参考。
As a vital component in traditional Chinese medicine anticancer prescriptions,the efficacy of Scutellaria baicalensis(Huangqin)has been thoroughly validated through modern pharmacological research,demonstrating not only anti-tumor and sedative-anxiolytic properties but also analgesic,antibacterial,and anti-inflammatory activities.Notably,baicalin,the active constituent of Huangqin,has become the focus of research both domestically and internationally in recent years due to its potent anti-tumor activity.Through reviewing relevant literatur,it has been established that baicalin exhibits remarkable therapeutic effects against liver,breast,ovarian,gastric,and various other types of cancers.Its mechanisms encompass inhibiting tumor cell proliferation and inducing tumor programmed cell death(PCD),such as apoptosis,pyroptosis and ferroptosis etc.PCD,as a crucial cellular biological process,plays a pervasive role in tumor initiation and progression.Thus,investigating the mechanisms underlying baicalin-induced PCD in tumor cells holds significant importance for identifying anti-tumor therapeutic targets.This review aims to summarize the mechanisms of baicalin-induced PCD in tumor cells,providing a reference for further research into its anti-tumor mechanisms of action.
作者
向强
赵勇
朱光辉
权哲
XIANG Qiang;ZHAO Yong;ZHU Guanghui;QUAN Zhe(Medical College of Anhui University of Science and Technology,Anhui 232001;Shanghai Clinical College of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine;Department of General Surgery,4Department of Neurology,Shanghai University of Traditional Chinese Medicine;Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine)
出处
《南通大学学报(医学版)》
2025年第1期52-57,共6页
Journal of Nantong University(Medical sciences)
基金
上海医学创新发展基金会中医药科技发展项目(WL-XJRY-2021010K)。
关键词
黄芩苷
程序性细胞死亡
抗肿瘤
作用机制
baicalin
programmed cell death
anti-tumor
mechanism of action
