摘要
随着各类新药的不断问世,复发或转移性头颈部鳞状细胞癌(R/M HNSCC)的治疗模式已由过去的全身化疗转变为免疫治疗、靶向治疗及多药联合模式。对于肿瘤负荷轻的局部复发或脏器转移有局部治疗条件者,再放疗及挽救性手术显示出良好的疗效。文章综述R/M HNSCC的治疗研究进展,强调根据患者的过往治疗经历、目前病情特点及免疫、基因状态给予个体化、精准化治疗,为R/M HNSCC的治疗选择提供合理建议。
With the introduction of new drugs,the treatment model for recurrent or metastatic head and neck squamous cell carcinoma(R/M HNSCC)has changed from systemic chemotherapy to immunotherapy,targeted therapy and multidrug combination.In addition,re-irradiation and salvage surgery have shown good clinical efficacy in patients with local recurrence of light tumor load or organ metastases with local treatment conditions.This article reviews the treatment progress of R/M HNSCC,and emphasizes the individualized and precise treatment based on the patient's past treatment experience,current disease characteristics and immune and genetic status to provide rational recommendations for treatment selection of R/M HNSCC.
作者
朱海英
田坤
周林
卫旭东
Zhu Haiying;Tian Kun;Zhou Lin;Wei Xudong(Department of Otolaryngology,the Fourth Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Oncology,the Second Hospital of Lanzhou University,Lanzhou 730030,China;Department of Otolaryngology,Gansu Provincial People's Hospital,Lanzhou 730000,China)
出处
《肿瘤研究与临床》
2025年第2期150-153,共4页
Cancer Research and Clinic
基金
兰州市人才创新创业项目(2021-RC-129)。
关键词
头颈部肿瘤
免疫疗法
分子靶向治疗
同步放化疗
复发
Head and neck neoplasms
Immunotherapy
Molecular targeted therapy
Concurrent chemoradiotherapy
Recurrence
