摘要
牛磺酸是机体内含量丰富的游离氨基酸,具有多种生理功能,在调节脂质代谢方面发挥着重要作用。牛磺酸能够促进胆固醇向胆汁酸的生物转化,并与胆汁酸生成牛磺酸结合型胆汁酸;可减少肝脏脂肪蓄积,显著改善肥胖。本文总结了牛磺酸及其衍生物的药理作用、临床应用及分析方法,特别是其影响脂质代谢的作用机制,梳理了中药及其复方通过调节牛磺酸和亚牛磺酸代谢通路影响脂质代谢紊乱的相关研究。牛磺酸在调节脂质代谢紊乱方面具有非常好的应用前景,牛磺酸和亚牛磺酸代谢通路是脂代谢紊乱调控的重要通路,本综述为牛磺酸的深入研究和临床应用提供理论依据,为相关药品和健康产品的开发提供参考。
Taurine is an abundant free amino acid in the body.It has many physiological functions and plays an important role in regulating lipid metabolism.Taurine can promote the biotransformation of cholesterol to bile acids and produce taurineconjugated bile acids with bile acids.It can reduce liver fat accumulation and significantly improve obesity.This paper summarizes the pharmacological effects,clinical application and analysis methods of taurine and its derivatives,especially the mechanism of its effect on lipid metabolism,and reviews the related research on the effect of traditional Chinese medicine and its compound on lipid metabolism disorder by regulating taurine and hypotaurine metabolic pathways.Taurine has a very good application prospect in regulating lipid metabolism disorders.Taurine and hypotaurine metabolic pathways are important pathways for the regulation of lipid metabolism disorders.This review provides a theoretical basis for the in-depth study and clinical application of taurine and provides a reference for the development of related drugs and health products.
作者
段丽婷
周连丽
雷娟红
程教丽
张范
杨兴鑫
郝俊杰
俞捷
DUAN Liting;ZHOU Lianli;LEI Juanhong;CHENG Jiaoli;ZHANG Fan;YANG Xingxin;HAO Junjie;YU Jie(Yunnan University of Traditional Chinese Medicine,Kunming 650500,China;Yunnan Key Laboratory of Southern Medicine Utilization,Kunming 650500,China;Science and Technology Achievement Incubation Center of Kunming Medical University,Kunming 650500,China)
出处
《中国现代应用药学》
北大核心
2025年第3期481-490,共10页
Chinese Journal of Modern Applied Pharmacy
基金
国家自然科学基金项目(82174037)
云南省基础研究杰出青年基金项目(202001AV070007)
云南省院士专家工作站(202205AF150019)
云南省基础研究面上项目(202101AY070001-077)。
关键词
牛磺酸
衍生物
脂质代谢
作用机制
taurine
derivative
lipid metabolism
mechanism of action
