摘要
“骨免疫”强调免疫系统与骨骼系统细胞间的相互作用,免疫失调会引起炎症刺激,释放出大量影响骨代谢的炎症因子。牙周炎是一种以牙菌斑为始动因子,宿主免疫炎症反应、遗传和环境等多种因素造成的牙周组织炎症性破坏的疾病。炎症反应和牙槽骨吸收是牙周炎的两大特征,免疫系统失调会引起骨稳态失衡(骨形成和吸收的平衡紊乱),导致牙槽骨丧失。黄酮类天然产物具有抗炎、抗氧化、促成骨及抗微生物等生物学活性,可有效改善过度炎症对牙周组织的损伤。本文概述了牙槽骨炎性吸收过程中可能涉及到的9条经典炎症信号通路,并从抑制炎症反应和调节炎症信号通路的方面梳理了近年来报道较多的20个黄酮类天然产物在抑制牙周炎相关牙周组织破坏方面的机制研究进展,以期为牙周炎的治疗策略提供理论基础和新的思路。
"Osteoimmunology"is a field that emphasizes the interaction between the immune system and skeletal system cells.Specifically,it explores how dysregulation of the immune system can result in inflammatory stimulation and the release of inflammatory factors,which significantly impact bone metabolism.Periodontitis is an inflammatory destructive disease of periodontal tissue,triggered initially by dental plaque and influenced by host immune inflammatory responses,genetic factors,and environmental factors.Inflammatory response and alveolar bone resorption stand out as prominent features of periodontitis,with immune system imbalance disrupting bone homeostasis,resulting in alveolar bone loss due to the imbalance of bone formation and resorption.Flavonoid natural products exhibit biological activities such as anti-inflammatory,antioxidant,osteogenic promotion,and antimicrobial effects,effectively ameliorating inflammatory damage to periodontal tissues.This paper provides an overview of nine classical inflammatory signaling pathways potentially involved in alveolar bone inflammatory resorption and reviews advancements in the mechanisms of action of 20 flavonoids reported for inhibiting periodontal tissue destruction associated with periodontitis by suppressing inflammatory responses and modulating inflammatory signaling pathways.The aim is to offer theoretical foundations and novel insights to enhance the treatment strategy of periodontitis.
作者
黄越
柳芳洲
赵奕菲
李悦瑞
白国辉
胡欢
HUANG Yue;LIU Fangzhou;ZHAO Yifei;LI Yuerui;BAI Guohui;HU Huan(School of Stomatology,Zunyi Medical University,Zunyi 563000,China;Microbial Resources and Drug Development Key Laboratory of Guizhou Tertiary Institution,Zunyi 563000,China)
出处
《中国药学杂志》
北大核心
2025年第2期153-165,共13页
Chinese Pharmaceutical Journal
基金
贵州省科技计划项目资助(黔科合基础-ZK[2021]一般439)
合肥市科技计划项目(遵市科合HZ字[2024]340号)
合肥医科大学2018年度学术新苗培养及创新探索专项项目资助(黔科合平台人才[2018]5772-010)。
关键词
天然产物
炎症反应
信号通路
牙周炎
骨免疫学
natural product
inflammatory response
signaling pathway
periodontitis
osteoimmunology
