摘要
食管癌是世界范围内肿瘤死亡的主要原因之一,放疗在食管癌的治疗中发挥重要作用,质子放疗由于其独特的生物物理学特性使其较光子放疗在剂量学上可降低危及器官的受量,可能是治疗食管癌的一种理想的放疗方式。在食管癌根治性放疗、新辅助放疗以及再程放疗中,质子放疗均发挥出重要的作用,疗效与光子放疗相当或更优,安全性更有优势。质子放疗与免疫治疗的联合、放疗剂量的提升、基于调强质子放疗技术的大型随机对照研究等将是后续研究的热点。
Esophageal cancer is one of the leading causes of death from cancer worldwide.Radiotherapy plays an important role in the treatment of esophageal cancer.Compared with photon radiotherapy,proton radiotherapy significantly reduces normal organ dose due to its unique biophysical properties,which makes this modality potential ideal for esophageal cancer treatment.Proton radiotherapy plays an important role in radical radiotherapy,neoadjuvant radiotherapy and re-radiotherapy for esophageal cancer.The efficacy is equivalent to or better than that of photon radiotherapy,and proton radiotherapy is superior than photon radiotherapy in security.The combination of proton radiotherapy and immunotherapy,the increase of radiotherapy dose,and large-scale randomized controlled studies based on intensity-modulated proton radiotherapy technology will be hot topics for further research.
作者
付成瑞
李宝生
黄伟
Fu Chengrui;Li Baosheng;Huang Wei(Department of Thoracic Radiotherapy,Cancer Hospital of Shandong First Medical University,Jinan 250117,China)
出处
《国际肿瘤学杂志》
2025年第1期48-52,共5页
Journal of International Oncology
关键词
食管肿瘤
放射疗法
质子疗法
Esophageal neoplasms
Radiotherapy
Proton therapy
