摘要
目的:探究慢性阻塞性肺疾病急性加重期(AECOPD)患者在雾化吸入治疗常规用药布地奈德的基础上,联合应用盐酸氨溴索的效果。方法:选取2022年9月—2024年8月中山市中山火炬开发区人民医院收治的124例AECOPD患者,将其随机分为对照组与研究组,各62例。对照组使用布地奈德雾化吸入治疗,研究组在对照组基础上联合应用盐酸氨溴索治疗。两组均治疗7 d。对比两组临床疗效、肺功能指标及症状缓解时间。结果:研究组治疗有效率为96.77%,高于对照组的79.03%,差异有统计学意义(P<0.05)。治疗后,研究组第1秒用力呼气量(FEV1)/用力肺活量、FEV1、呼气峰流速值、25%最大呼气流量均高于对照组,差异有统计学意义(P<0.05)。研究组咳嗽、咳痰、喘息、憋闷、肺部湿啰音的缓解时间均短于对照组,差异有统计学意义(P<0.05)。结论:盐酸氨溴索联合布地奈德雾化吸入治疗AECOPD患者的疗效确切,能加快临床症状缓解进程,改善肺功能,具有一定的临床应用意义。
Objective:To explore the effect of Ambroxol Hydrochloride combined with Budesonide in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:A total of 124 AECOPD patients admitted to Zhongshan Torch Development Zone People’s Hospital from September 2022 to August 2024 were randomly divided into a control group and a study group,with 62 cases in each group.The control group was treated with Budesonide aerosol inhalation,and the study group was treated with Ambroxol Hydrochloride on the basis of the control group.Both groups were treated for 7 days.The clinical efficacy,pulmonary function index and symptom remission time of the two groups were compared.Results:The effective rate of the study group was 96.77%,higher than 79.03%of the control group,the difference was statistically significant(P<0.05).After treatment,forced expiratory volume(FEV1)/forced vital capacity,FEV1,peak expiratory flow rate and 25%maximum expiratory flow in the study group were higher than those in the control group,with statistical significance(P<0.05).The relief time of cough,expectoration,wheezing,suffrage and pulmonary moist rales in the study group were shorter than those in the control group,with statistical significance(P<0.05).Conclusion:Ambroxol Hydrochloride combined with Budesonide aerosol inhalation is effective in the treatment of AECOPD patients,which can accelerate the process of clinical symptom relief and improve lung function,and has certain clinical application significance.
作者
崔林杰
何平
CUI Linjie;HE Ping(Department of Respiratory and Critical Care Medicine,People’s Hospital of Zhongshan Torch Development Zone,Zhongshan 528400,China)
出处
《中国伤残医学》
2024年第24期57-60,共4页
Chinese Journal of Trauma and Disability Medicine
关键词
慢性阻塞性肺疾病急性加重期
雾化吸入
布地奈德
盐酸氨溴索
效果
肺功能
Chronic obstructive pulmonary diseases acute exacerbation period
Atomizing inhalation
Budesonide
Ambroxol Hydrochloride
Effect
Lung function
