摘要
目的探讨红细胞分布宽度(RDW)比率/血红蛋白(Hb)比值对晚期胃癌患者一线化疗疗效、预后的预测价值。方法选取2019年6月至2021年12月于山西医科大学第一临床医学院接受一线化疗方案治疗的120例晚期胃癌患者为研究组,根据疗效分为敏感组(n=42)和不敏感组(n=78);另选100名健康体检者作为对照组。比较研究组和对照组、敏感组和不敏感组RDW、Hb及RDW/Hb比值。采用受试者工作特征(ROC)曲线评价RDW/Hb比值对晚期胃癌患者一线化疗疗效的预测价值。采用Cox回归分析探讨晚期胃癌患者预后影响因素。结果研究组RDW、RDW/Hb比值高于对照组,Hb低于对照组(P<0.05)。不敏感组患者RDW、RDW/Hb比值高于敏感组,Hb低于敏感组(P<0.05)。RDW、Hb及RDW/Hb比值预测晚期胃癌患者一线化疗疗效的AUC分别为0.731、0.847、0.922。根据RDW/Hb比值最佳截点值1.21将研究组分为高RDW/Hb比值组(n=82)、低RDW/Hb比值组(n=38)。生存分析表明,120晚期胃癌患者中位生存时间11个月。与高RDW/Hb比值组相比,低RDW/Hb比值组晚期胃癌患者OS明显延长(P<0.05)。多因素分析显示,化疗耐药、低分化、RDW/Hb比值≥1.21是晚期胃癌患者预后的影响因素(P<0.05)。结论RDW/Hb比值在预测晚期胃癌患者一线化疗疗效及预后方面具有良好的临床价值。
Objective To explore the value of RDW ratio/Hb ratio in predicting the efficacy and prognosis of first⁃line chemotherapy in patients with advanced gastric cancer.Methods A total of 120 patients with advanced gastric cancer(study group)who received first⁃line chemotherapy from June 2019 to December 2021 were selected and divided into a sensitive group(n=42)and an insensitive group(n=78)based on chemotherapy efficacy.Another 100 healthy subjects were chosen as the control group.The RDW,Hb,and RDW/Hb ratio were compared between the study group and the control group,as well as between the sensitive and insensitive groups.The predictive value of the RDW/Hb ratio for first⁃line chemotherapy in patients with advanced gastric cancer was evaluated using ROC analysis.The prognostic factors in patients with advanced gastric cancer were investigated using Cox regression.Results The RDW and RDW/Hb ratio of the research group were higher than those of the control group,while Hb was lower than that of the control group(P<0.05).The RDW and RDW/Hb ratio of patients in the insensitive group were higher than those in the sensitive group,while Hb was lower than that in the sensitive group(P<0.05).The AUC values of RDW,Hb,and RDW/Hb ratio for predicting first⁃line chemotherapy efficacy in advanced gastric cancer patients were 0.731,0.847,and 0.922,respectively.According to the optimal cut⁃off value of 1.21 for RDW/Hb ratio,the study group was divided into high RDW/Hb ratio group(n=82)and a low RDW/Hb ratio group(n=38).Survival analysis shows that the median survival time of 120 patients with advanced gastric cancer is 11 months.Compared with the high RDW/Hb ratio group,the low RDW/Hb ratio group showed significantly prolonged OS in advanced gastric cancer patients(P<0.05).Multivariate analysis showed that chemotherapy resistance,low differentiation,and a RDW/Hb ratio≥1.21 were prognostic factors for advanced gastric cancer patients(P<0.05).Conclusion The RDW/Hb ratio has good clinical value in predicting the efficacy of first⁃line chemotherapy and prognosis in patients with advanced gastric cancer.
作者
王卉
张革红
相辉艳
刘强
张丽欣
张玉洁
WANG Hui;ZHANG Gehong;XIANG Huiyan;LIU Qiang;ZHANG Lixin;ZHANG Yujie(The First Clinical Medical college of Shanxi Medical University,Taiyuan,Shanxi,China,030000;Department of General Oncology,the First Clinical Medical college of shani Medical University Taiyuan,Shanxi,China,030000;Department of Emergency,Changzhi People's Hospital,Changzhi,Shanxi,China,046000;Department of Clinical Laboratory,Changzhi People's Hospital,Changzhi,Shanxi,China,046000)
出处
《分子诊断与治疗杂志》
2025年第1期154-158,共5页
Journal of Molecular Diagnostics and Therapy
基金
北京市希思科临床肿瘤学研究基金会(Y⁃Q201801⁃034)。
关键词
红细胞分布宽度/血红蛋白比值
晚期胃癌
疗效
预后
Red blood cell distribution width/hemoglobin ratio
Advanced gastric cancer
Curative effect
Prognosis
