摘要
目的分析通脉汤联合阿司匹林对髋部骨折患者血栓前状态及miR⁃374b⁃5p、IL⁃6的影响。方法选取2022年1月至2024年2月河南省洛阳正骨医院收治的108例髋部骨折患者为研究对象,根据治疗方式的差异,分为研究组(n=55)和对照组(n=53),两组均给予常规预防方法,对照组患者在常规治疗的基础给予阿司匹林治疗,研究组在常规治疗和阿司匹林治疗的基础上联合通脉汤治疗。比较两组治疗后的临床指标(总输血量、红细胞压积变化率、血红蛋白变化率)、血栓形成情况和不良反应,并比较两组治疗前后的血栓前状态(纤维蛋白原降解产物、抗凝血酶⁃3、D⁃二聚体)以及miR⁃374b⁃5p、IL⁃6水平。结果研究组的输血量、红细胞压积变化率、血红蛋白变化率、血栓形成率均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组纤维蛋白原降解产物、抗凝血酶⁃3、D⁃二聚体均较治疗前改善,且研究组优于对照组,差异有统计学意义(P<0.05)。两组治疗后的miR⁃374b⁃5p、IL⁃6均较治疗前降低,且研究组低于对照组,差异有统计学意义(P<0.05)。两组不良反应比较差异无统计学意义(P>0.05)。结论通脉汤联合阿司匹林可有效改善髋部骨折患者血栓前状态,预防血栓形成,且可降低miR⁃374b⁃5p、IL⁃6水平。
Objective To analyze the effects of Tongmai Decoction combined with aspirin on prethrombotic status,miR⁃374b⁃5p,and IL⁃6 in patients with hip fracture.Methods 108 patients with hip fractures who were admitted to Luoyang Orthopedic Hospital,Henan Province from January 2022 to February 2024 were selected for this study.They were dicided into two groups based on treatment methods:the study group(n=55)and the control group(n=53).Both groups received conventional preventive methods,with the control group also receiving aspirin in addition to the usual treatment.The study group,on the other hand,received Tongmai Decoction alongside the conventional treatment and aspirin.After treatment,clinical indicators such as total transfusion volume,hematocrit change rate,hemoglobin change rate,as well as occurrence of thrombosis and adverse reactions,were compared between the two groups.Additionally,the pre⁃thrombotic status(fibrinogen degradation products,antithrombinase⁃3,D⁃dimer),miR⁃374b⁃5p,and IL⁃6 levels were compared between the two groups before and after treatment.Results The blood transfusion volume,hematocrit change rate,hemoglobin change rate,and thrombosis rate in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the fibrinogen degradation products,antithrombin⁃3,and D⁃dimer in both groups improved compared to before treatment,with the study group showing better results than the control group,and the differences were statistically significant(P<0.05).Following treatment,the levels of miR⁃374b⁃5p and IL⁃6 in tboth groups were lower than before treatment,with the study group showing lower levels than the control group,and the differences were statistically significant(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion The combination of Tongmai Decoction combined and aspirin can improve the pre⁃thrombotic status of patients with hip fractures,prevent thrombosis,and reduce the levels of miR⁃374b⁃5p and IL⁃6.
作者
刘超
孟旭初
王继涛
LIU Chao;MENG Xuchu;WANG Jitao(Department of Pelvic and Acetabular Surgery,Luoyang Orthopaedic Hospital,Luoyang,Henan,China,471000)
出处
《分子诊断与治疗杂志》
2025年第1期92-95,共4页
Journal of Molecular Diagnostics and Therapy
基金
河南省科技攻关项目(232102310423)。
