摘要
神经损伤是骨科和神经科医师共同面临的棘手问题,目前尚无确切有效的治疗方法。血管生成素(Ang)是一种血管生成因子,近年来,Ang的神经保护作用逐渐被发现。Ang可以通过促进新血管生成、维持血脑屏障和血脊髓屏障的稳定性、抑制神经损伤后的炎症反应和毒性离子进入神经细胞起神经保护作用。重要的是,Ang可以直接作用于神经细胞抑制损伤后细胞的自噬和凋亡。本文就Ang在神经系统损伤中的保护作用及其机制进行综述,为探索其成为新型神经保护因子提供研究思路。
Nerve damage poses a complex challenge for orthopedists and neurologists,currently with no definitive and effective treatment available.Angiopoietin(Ang)is recognized as an angiogenic factor,and its neuroprotective properties has been unveiled in recent years.Ang demonstrates neuroprotective capabilities by promoting angiogenesis,maintaining the integrity of the blood-brain barrier and blood-spinal cord barrier,as well as suppressing inflammatory responses and the influx of harmful ions into nerve cells post-injury.Notably,Ang can directly act on nerve cells by inhibiting autophagy and apoptosis following injury.In this article,we reviewed the neuroprotective effects and underlying mechanisms of Ang in the nervous system,offering valuable insights for further exploration of its potential as a novel neuroprotective agent.
作者
贾小龙
孙超
Jia Xiaolong;Sun Chao(Department of Orthopedics,Affiliated Jiangning Hospital of Nanjing Medical University,Nanjing 211100,China)
出处
《中华老年多器官疾病杂志》
2025年第2期153-156,共4页
Chinese Journal of Multiple Organ Diseases in the Elderly
基金
江苏省自然科学基金(SBK20221176)。
关键词
血管生成素
神经损伤
脊髓损伤
炎症反应
angiopoietin
nerve damage
spinal cord injury
inflammatory response
