摘要
目的研究腹泻型肠易激综合征(diarrhea-predominant irritable bowel syndrome,IBS-D)人群与健康人群肠道菌群特征及其差异,为IBS-D的基础研究提供临床依据。方法选取2023年1月至2024年6月温州市人民医院收治的IBS-D患者32例为IBS-D组,选取同一时期33名健康者为对照组。对粪便进行菌群的16S rDNA检测,对DNA进行定量分析菌群多样性。结果IBS-D组患者较对照组的多样性明显减少,在门水平比较,IBS-D组患者较对照组变形菌门相对丰度升高;在属水平比较,IBS-D组患者的大肠杆菌-志贺菌属、克雷伯菌属相对丰度升高。结论IBS-D患者肠道菌群多样性减少,变形菌门是IBS-D的潜在致病菌。
Objective To study the characteristics of intestinal flora between diarrhea-predominant irritable bowel syndrome(IBS-D)and healthy population,and to provide a clinical basis for the basic research of IBS-D.Methods A total of 32 IBS-D patients admitted to Wenzhou People’s Hospital,the Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University from January 2023 to June 2024 were selected as IBS-D group,and 33 healthy during the same period as control group.Cluster diversity was determined by 16S rDNA of clusters in feces and quantification of DNA.Results The diversity of IBS-D group decreased significantly than control group,and the relative abundance of proteobacteria increased in the IBS-D group,and the relative abundance of E.coli-Shigella and Klebsiella increased in the IBS-D group.Conclusion Intestinal microbiota diversity in IBS-D patients reduced and proteobacteria is the potential pathogen of IBS-D.
作者
宋彩云
兰巧丽
林晓晓
翁雪健
郑恩典
SONG Caiyun;LAN Qiaoli;LIN Xiaoxiao;WENG Xuejian;ZHENG Endian(Department of Gastroenterology,Wenzhou People’s Hospital,the Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University,Wenzhou 325000,Zhejiang,China)
出处
《中国现代医生》
2025年第5期42-44,共3页
China Modern Doctor
基金
浙江省温州市科学技术局项目(Y20220334)。
