摘要
[目的]分析安徽省城市肺癌筛查项目的成本效果和成本效用,为安徽省制定肺癌筛查政策提供建议。[方法]基于现场调研数据和文献数据,建立低剂量螺旋CT(low-dose computed tomography,LDCT)肺癌筛查干预的Markov决策模型。模拟不同干预下人群的发展情况,使用挽救的生命年(saved life years,LYS)、质量调整生命年(quality-adjusted life years,QALY)作为效果指标,对不同筛查策略进行成本效果、成本效用分析。成本数据以3%贴现率进行贴现。[结果] 1年1次、2年1次、3年1次、5年1次的筛查方案每挽救1个LYS或QALY均符合成本效果原则。其中,成本效果比与成本效用比最好的筛查策略均为2年1次LDCT肺癌筛查策略,每挽救1个LYS或QALY成本最少,分别为72 441.54、71 050.24元。[结论] LDCT肺癌筛查方案具有良好的成本效果,不同筛查频次的策略均为可选策略,最佳筛查策略为2年1次。
[Purpose]To analyze the cost-effectiveness and cost-utility conducted on the lung cancer screening project in urban areas of Anhui Province,and to provide suggestions for the formulation of lung cancer screening policies in Anhui Province.[Methods]A Markov decision model for low-dose computed tomography(LDCT)lung cancer screening intervention was established based on on-site survey data and literature data.The development of the population under different interventions was simulated,using saved life years(LYS)and quality-adjusted life years(QALY)as effectiveness indicators,to conduct cost-effectiveness and cost-utility analyses of different screening strategies.Cost data were discounted at a 3%discount rate.[Results]The screening schemes of once a year,once every two years,once every three years,and once every five years all meet the cost-effectiveness principle for saving one LYS or QALY.Among them,the best screening strategy in terms of cost-effectiveness and cost-utility was the LDCT lung cancer screening strategy once every two years,with costs of 72441.54 CNY and 71050.24 CNY,respectively.[Conclusion]The LDCT lung cancer screening program demonstrates good cost-effectiveness,with strategies of different screening frequencies being viable options.The optimal screening strategy is screening once every two years.
作者
王莉
刘慧婷
钱立庭
魏东华
马艳玲
邹明明
王德斌
柴静
WANG Li;LIU Huiting;QIAN Liting;WEI Donghua;MA Yanling;ZOU Mingming;WANG Debin;CHAI Jing(School of Health Management,Anhui Medical University,Hefei 230032,China;The First Affiliated Hospital of USTC(Anhui Provincial Hospital)/Anhui Provincial Cancer Hospital Office of Early Diagnosis and Treatment of Urban Cancer,Hefei 230031,China;The Second People's Hospital of Hefei,Hefei 230011,China)
出处
《中国肿瘤》
北大核心
2025年第2期132-137,共6页
China Cancer
基金
安徽省自然科学基金(2208085MG189)
国家城市癌症早诊早治项目。
关键词
低剂量螺旋CT
筛查
成本效果分析
成本效用分析
安徽
low-dose computed tomography
screening
cost-effectiveness analysis
cost-utility analysis
Anhui
