摘要
目的:探讨瑞马唑仑对甲状腺手术患者麻醉效果、安全性及血流动力学的影响。方法:选取2020年1月—2024年4月连云港市赣榆区人民医院收治的64例甲状腺手术患者作为研究对象,以随机数表法分为对照组和观察组,各32例。两组采用相同的麻醉方式诱导,对照组采用咪达唑仑,观察组给予瑞马唑仑,比较两组麻醉效果、血流动力学[血压、心率(heart rate,HR)、血氧饱和度(blood oxygen saturation,SpO_(2))]、应激反应[皮质醇(cortisol,Cor)、肾上腺素(epinephrine,E)、过氧化氢(hydrogen peroxide,H_(2)O_(2))、丙二醛(malondialdehyde,MDA)]及安全性。结果:观察组睁眼时间、气管拔管时间、麻醉后监测治疗室(postanesthesia care unit,PACU)停留时间、意识恢复时间短于对照组,术后1 h Ramsay评分高于对照组,术后1 h数字疼痛评分法(numeric rating scale,NRS)评分低于对照组,差异有统计学意义(P<0.05);麻醉后15 min,两组舒张压、收缩压和HR升高,但观察组低于对照组,差异有统计学意义(P<0.05);术后,两组E、H_(2)O_(2)、Cor、MDA水平升高,但观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率和麻醉后15 min SpO_(2)比较,差异无统计学意义(P>0.05)。结论:瑞马唑仑应用于甲状腺手术麻醉诱导中,可提升麻醉效果和安全性,且对患者血流动力学影响较小,并可缓解应激反应。
Objective:To explore the influence of Remimazolam on anaesthesia effect,safety and haemodynamics in patients undergoing thyroid surgery.Method:A total of 64 patients undergoing thyroid surgery who admitted to Ganyu District People's Hospital in Lianyungang City from January 2020 to April 2024 were selected as the research objects,and they were divided into the control group and the observation group by random number table method,with 32 cases in each group.Two groups were induced by the same anesthesia method,the control group was treated with Midazolam,and the observation group was given Remimazolam,the anesthetic effect,hemodynamics[blood pressure,heart rate(HR),blood oxygen saturation(SpO_(2))],stress response[cortisol(Cor),epinephrine(E),hydrogen peroxide(H_(2)O_(2)),malondialdehyde(MDA)]and safety were compared between two groups.Result:The times of eye opening,tracheal extubation,postanesthesia care unit(PACU)stay and consciousness recovery in the observation group were shorter than those in the control group,the Ramsay score at 1 h after operation was higher than that in the control group,and the numeric rating scale(NRS)score at 1 h after operation was lower than that in the control group,the differences were statistically significant(P<0.05);at 15 min after anesthesia,the diastolic blood pressure,systolic blood pressure and HR of two groups were increased,but those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05);after operation,the levels of E,H_(2)O_(2),Cor and MDA in two groups were increased,but those in the observation group were lower than the control group,the differences were statistically significant(P<0.05);there were no significant differences in the incidence of adverse reactions and SpO_(2) at 15 min after anesthesia between two groups(P>0.05).Conclusion:The application of Remimazolam in the anesthesia induction of thyroid surgery can improve the anesthesia effect and safety,and has little effect on the hemodynamics of patients,and can alleviate the stress response.
作者
董磊
DONG Lei(Ganyu District People's Hospital in Lianyungang City,Lianyungang 222100,China)
出处
《中外医学研究》
2025年第5期21-24,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
