摘要
目的基于MemTrax迈睦睿记忆测量程序探讨慢性失眠患者失眠严重程度的相关因素。方法选取广东省中医院治未病中心自2024年4月至2024年9月收治或院内广告招募的220例慢性失眠(每周失眠≥3 d,病程≥3个月)患者为研究对象,采用匹兹堡睡眠质量指数(PSQI)量表评估患者近1个月的睡眠质量,根据PSQI评分将患者分为轻度失眠组(7~10分)、中度失眠组(11~15分)、重度失眠组(16~21分)。采用MemTrax迈睦睿记忆测量程序评估患者的认知记忆功能,采用患者健康问卷-9(PHQ-9)、广泛性焦虑障碍-7(GAD-7)量表评价患者近2周的抑郁、焦虑程度。比较不同程度慢性失眠患者临床资料、MemTrax测试结果和PHQ-9、GAD-7评分的差异。采用Spearman秩相关性检验分析慢性失眠患者失眠严重程度与认知记忆功能等临床资料的相关性。结果220例慢性失眠患者中,轻度、中度、重度失眠患者分别为54、111、55例。与轻度、中度失眠组患者比较,重度失眠组患者中年龄>50岁者占比较高,使用安眠类药物者占比较高,差异均有统计学意义(P<0.05)。重度失眠组患者图片识别正确率[84%(78%,92%)]低于轻度、中度失眠组患者[90%(86%,94%)、88%(82%,94%)],MemTrax综合指数(76.69±17.43)低于轻度、中度失眠组患者(88.55±18.67、84.41±20.93),PHQ-9评分[12(8,16)分]高于轻度、中度失眠组患者[9(6,11)分、9(6,15)分],差异均有统计学意义(P<0.05);与轻度失眠组患者比较,重度失眠组患者图片识别反应时间较长[1.04(0.90,1.15)s比1.11(1.03,1.24)s],GAD-7评分较高[6(3,9)分比7(5,13)分],差异均有统计学意义(P<0.05)。相关性分析结果显示慢性失眠患者的失眠严重程度与年龄、PHQ-9评分、GAD-7评分、图片识别反应时间呈正相关关系(P<0.05),与图片识别正确率、MemTrax综合指数呈负相关关系(P<0.05)。结论慢性失眠患者的失眠严重程度与年龄、认知记忆功能、抑郁焦虑程度有关。
Objective To explore the correlative factors for insomnia severity in chronic insomnia patients using MemTrax memory test.Methods Two hundred and twenty-two chronic insomnia patients(insomnia≥3 days per week with a duration≥3 months)recruited from Center for Preventive Treatment of Diseases,Guangdong Provincial Hospital of Chinese Medicine or through in-hospital advertisements from April 2024 to September 2024 were chosen.Pittsburgh Sleep Quality Index(PSQI)was used to evaluate the sleep quality over the last month;according to PSQI score,these patients were divided into mild insomnia group(scores of 7-10),moderate insomnia group(scores of 11-15)and severe insomnia group(scores of 16-21).MemTrax memory test was used to record the picture recognition accuracy and picture recognition reaction time,and MemTrax comprehensive index(MTx-Cp)was calculated;Patients'Health Questionnaire(PHQ-9),and Generalized Anxiety Disorder-7 scale(GAD-7)were used to evaluate the depression and anxiety status of these patients in recent 2 weeks.The clinical data,MemTrax test results,PHQ-9 and GAD-7 scores of patients with different degrees of chronic insomnia were compared.Spearman rank correlation analysis was used to investigate the correlation between insomnia severity and clinical data such as cognitive memory function in chronic insomnia patients.Results Among the 220 chronic insomnia patients,54 had mild insomnia,111 had moderate insomnia,and 55 had severe insomnia.Severe insomnia patients had significantly higher percentages of those>50 years old and those using hypnotics compared with mild insomnia patients and moderate insomnia patients(P<0.05).Compared with the mild insomnia patients and moderate insomnia patients,the severe insomnia patients exhibited significantly lower picture recognition accuracy(90%[86%,94%],88%[82%,94%],84%[78%,92%]),significantly lower MTx-Cp(88.55±18.67,84.41±20.93,76.69±17.43),and significantly higher PHQ-9 score(9[6,11],9[6,15],12[8,16],P<0.05).Moreover,severe insomnia patients had significantly longer picture recognition reaction time and higher GAD-7 score than mild insomnia patients(1.11[1.03,1.24]s vs.1.04[0.90,1.15]s;7[5,13]vs.6[3,9],P<0.05).Spearman rank correlation analysis showed that insomnia severity in chronic insomnia patients was positively correlated with age,PHQ-9 score,GAD-7 score,and picture recognition reaction time,and negatively correlated with picture recognition accuracy and MTx-Cp(P<0.05).Conclusion Insomnia severity in patients with chronic insomnia is correlated with age,cognitive memory function,depression and anxiety.
作者
冉星雨
刘雨茜
孙晨
罗文晰
陈伟能
苏凤娟
徐福平
裴中
Ran Xingyu;Liu Yuxi;Sun Chen;Luo Wenxi;Chen Weineng;Su Fengjuan;Xu Fuping;Pei Zhong(Second Clinical Medical College of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Center for Preventive Treatment of Diseases,Guangdong Provincial Hospital of Chinese Medicine(Second Affiliated Hospital of Guangzhou University of Chinese Medicine),Guangzhou 510120,China;Department of Neurology,First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China)
出处
《中华神经医学杂志》
北大核心
2025年第2期147-153,共7页
Chinese Journal of Neuromedicine
基金
广东省基础与应用基础研究基金企业联合基金(2022A1515220073)
广州市科技计划项目(2023A03J0736)
广州市科技局市校联合项目(2023A03J0754)
广东省中医院院内专项(YN2020ZWB04)。
关键词
慢性失眠
焦虑
抑郁
认知记忆
Chronic insomnia
Anxiety
Depression
Cognitive memory
