摘要
肺炎支原体肺炎(Mycoplasma pneumoniae pneumonia,MPP)近年来重症率和难治率逐渐升高,其中免疫损伤被认为是重要的致病机制。炎症指数是一类通过血常规指标计算得出的组合炎症指标,可反映机体的全身炎症状态,在儿童MPP的临床应用中具有重要潜力。目前,中性粒细胞与淋巴细胞比值已被广泛认可,其在预测疾病严重程度、并发症及预后评估方面的价值得到了较为一致的肯定。此外,其他炎症指数,如淋巴细胞与单核细胞比值、血小板与淋巴细胞比值以及系统性免疫炎症指数等,也在相关研究中展现了良好的应用前景。本文将简要概述MPP的免疫损伤机制,并重点讨论炎症指数在儿童MPP中的临床应用,为MPP的早期诊断与评估提供新的参考依据。
The incidence of severe and refractory cases of Mycoplasma pneumoniae pneumonia(MPP)has been increasing,with immune impairment playing a critical role in its pathogenesis.Inflammatory indices,calculated from routine blood parameters,are a set of combined indicators that reflect systemic inflammation and show promise in the diagnosis and evaluation of MPP.Among these,the neutrophil-to-lymphocyte ratio has been consistently recognized for its value in predicting disease severity,complications,and prognosis.Other inflammatory indices,such as the lymphocyte-to-monocyte ratio,platelet-to-lymphocyte ratio,and systemic immunoinflammatory index,also demonstrate clinical significance.This review provides a concise overview of the immune impairment mechanisms in MPP and highlights the potential applications of inflammatory indices,aiming to offer valuable insights for the early diagnosis and assessment of MPP.
作者
张睿
刘峰
ZHANG Rui;LIU Feng(Department of Respiratory Medicine,Children’s Hospital of Nanjing Medical University,Nanjing 210008,China)
出处
《传染病信息》
2025年第1期89-92,102,共5页
Infectious Disease Information
基金
国家自然科学基金(82270008)。
