期刊文献+

APL转为AML部分分化型模式的初步探讨

Preliminary study on the transformation of partial differentiation model of APL into AML
暂未订购
导出
摘要 急性早幼粒细胞白血病(acute promyelocytic leukemia,APL)的特征是粒细胞分化受阻,白血病细胞停止在早幼粒细胞阶段,95%的患者可检出t(15;17)(q24;q21),这种染色体易位导致PML-RARA融合基因的形成[1]。APL的经典治疗是全反式维甲酸(all-trans retinoic acid,ATRA)和三氧化二砷(arsenic trioxide,ATO),80%~90%的患者可以通过ATRA、ATO及其它化疗药物的结合而治愈[2]。
作者 陈穆群 王进 尹霜梅 朱莹 姚昔友 CHEN Muqun;WANG Jin;YIN Shuangmei
出处 《云南医药》 2025年第1期118-120,共3页 Medicine and Pharmacy of Yunnan
  • 相关文献

参考文献7

二级参考文献19

  • 1展昭民,陈德发,吴红菊,贡铁军,任实,郝文鹏,唐庆华,关小军,张伯龙,马军.治疗相关性白血病的治疗[J].癌症进展,2005,3(2):106-109. 被引量:12
  • 2Wang ZY, Chert Z. Acute promyelocytic leukemia: from highly fatal to highly curable. Blood, 2008 ; 111 (5) : 2505 - 2515.
  • 3Foran JM. New prognostic markers in acute myeloid leukemia: perspective from the clinic. Hematology Am Soc Hematol Educ Program, 2010 ;2010 : 47 - 55.
  • 4Callens C, Chevret S, Cayuela JM, et al. Prognostic implication of FLT3 and Ras gene mutations in patients with acute promyelocytic leukemia (APL): a retrospective study from the European APL Group. Leukemia, 2005 ; 19 (7) : 1153 - 1160.
  • 5Florian K, Claudia S, Wolfgang K, et al. Impact of FLT3 mutations and promyelocytic leukaemia-breakpoint on clinical characteristics and prognosis in acute promyelocytic leukaemia. Br J Haematol, 2005; 130(2) : 196-202.
  • 6Rosemary E. G, Robert H, Arnold R. P, et al. Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia. Blood, 2005 ; 106 (12) : 3768 - 3776.
  • 7Chou WC, Chou SC, Liu CY, et al. TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics. Blood, 2011 ; 118 ( 14 ) : 3803 -3810.
  • 8Phoenix A. Ho, Rong Z, Todd A. A, et al. Prevalence and prognostic implications of WT1 mutations in pediatric acute myeloid leukemia (AML) : a report from the Children's Oncology Group. Blood, 2010; 116(5) : 702 -710.
  • 9Oki K, Takital J, Hiwatari M, et al. IDH1 and IDH2 mutations are rare in pediatric myeloid malignancies. Leukemia, 2011 ; 25 (2) : 382 -384.
  • 10徐菁,王宏伟,杨涛覃,艳红张丽.急性髓系白血病患者白血病干细胞WT1基因表达水平及其临床意义[J].中华血液学杂志,2010,31(3):172-175. 被引量:5

共引文献16

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部