摘要
Gastrointestinal stromal tumors(GIST)are the most common mesenchymalderived tumors of the GI tract.They can occur throughout the GI tract,and the survival time of some patients can be improved by first-line targeted therapy with imatinib.However,there are some limitations with imatinib treatment.Immunotherapy for GIST has attracted much attention in recent years,and as one of the most abundant cells in the GIST microenvironment,M2 macrophages play an important role in disease progression.They have unique anti-inflammatory and pro-tumorigenic effects and are one target for immunotherapy.This review summarizes the connection between different factors and the programmed death receptor-1/programmed death ligand-1 pathway and M2 macrophages to reactivate or enhance anti-tumor immunity and improve imatinib efficacy,and to provide new ideas for GIST immunotherapy.
基金
Supported by the National Natural Science Foundation of China,No.82160842
Clinical Research Project of Research Fund of Gansu Provincial Hospital,No.23GSSYD-17.
