摘要
目的评估益气养阴祛风方治疗早期气阴两虚型IgA肾病的临床疗效,并探讨其对氧化应激的影响。方法选取2020年9月至2023年9月在浙江中医药大学附属第一医院就诊,经肾活检确诊为早期IgA肾病患者70例作为研究对象。根据患者自行选择的治疗方案,分为观察组(n=38)和对照组(n=25)。对照组接受西医基础治疗;观察组在接受西医基础治疗的同时联合益气养阴祛风方。随访12周,评估两组患者的疗效,并比较两组患者血清中氧化应激的情况。结果治疗前后两组患者的中医证候积分均显著下降,且观察组中医证候积分明显低于对照组(P<0.05)。观察组总有效率为92.1%,对照组总有效率为56.0%,两组患者总有效率差异有统计学意义(P<0.05)。两组患者治疗后尿中红细胞及尿蛋白/肌酐比值与治疗前比较均有下降,差异有统计学意义,且观察组患者的尿红细胞和尿蛋白/尿肌酐指标下降幅度大于对照组(P<0.05)。与治疗前比较,治疗后两组患者血清中超氧化物歧化酶(SOD)水平明显上升,丙二醛(MDA)水平显著下降,且观察组患者血清SOD水平升幅和MDA水平降幅均高于对照组,差异均具有统计学意义(P<0.05)。两组患者在治疗前后的肾功能指标差异无统计学意义(P>0.05)。结论西医联合益气养阴祛风方能显著改善早期IgA肾病患者的临床症状,降低尿红细胞、尿蛋白/尿肌酐比值等临床指标,对肾功能有保护作用,其作用机制可能与调节氧化应激有关。
Objective To evaluate the clinical efficacy of Yiqi Yangyin Qufeng formula in treating early-stage IgA nephropathy(IgAN)with Qi and Yin deficiency,and to explore its impact on oxidative stress.Methods A total of 70 patients with early-stage IgAN,confirmed by renal biopsy at the First Affiliated Hospital of Zhejiang Chinese Medical University from September 2020 to September 2023,were selected as the study subjects.Patients were divided into an observation group(n=38)and a control group(n=25)based on their chosen treatment plan.The control group received Western medicinebased treatment,while the observation group received Western medicine-based treatment combined with Yiqi Yangyin Qufeng formula.After a 12-week follow-up,the therapeutic effects of both groups were evaluated,and the oxidative stress in the serum of patients in both groups was compared.Results The traditional Chinese medicine symptom scores of both groups significantly decreased after treatment,with the observation group showing a markedly lower score than the control group(P<0.05).The total effective rate of the observation group was 92.1%,and that of the control group was 56.0%,with a statistically significant difference between the two groups(P<0.05).The levels of urinary red blood cells and urine protein/creatinine ratio in both groups decreased after treatment compared to before treatment,with statistically significant differences,and the observation group showed a greater decrease in urinary red blood cells and urine protein/creatinine ratio than the control group(P<0.05).Compared to before treatment,the levels of superoxide dismutase(SOD)in the serum of both groups significantly increased,and malondialdehyde(MDA)levels significantly decreased after treatment,with the observation group showing a greater increase in SOD levels and a greater decrease in MDA levels than the control group,with statistically significant differences(P<0.05).There was no statistically significant difference in renal function indicators between the two groups before and after treatment(P>0.05).Conclusion The combination of Western medicine with Yiqi Yangyin Qufeng Decoction can significantly improve the clinical symptoms of patients with early IgAN,reduce clinical indicators such as urinary red blood cells and the urinary protein/creatinine ratio,and has a protective effect on renal function.Its mechanism of action may be related to the regulation of oxidative stress.
出处
《浙江临床医学》
2025年第2期206-208,共3页
Zhejiang Clinical Medical Journal
基金
浙江省中医药科技计划项目(2020ZZ008)
浙江省科技厅2024年度“尖兵领雁+X”研发攻关计划项目(2024C03214)。
关键词
益气养阴祛风方
IGA肾病
气阴两虚
态靶辨证
氧化应激
Yiqi Yangyin Qufeng formula
IgA nephropathy
Qi and Yin deficiency
State-target syndrome differentiation
Oxidative stress
