摘要
目的探讨淫羊藿苷(icariin,ICA)对卵巢癌(ovarian cancer,OC)的作用及其可能机制。方法采用生物信息学分析方法,通过网络药理学鉴定ICA靶向基因和OC相关信号通路,检索2001年6月—2023年6月的PubMed、EMBASE和Web of Science中的细胞实验,以评估传统ICA与安慰剂对OC的影响,并确定了文章中涉及的途径和基因,对文献中的治疗靶点进行统计分析。结果共检索了76项研究,其中8项研究的数据符合纳入标准。对成功验证的14个靶基因进行分析,发现它们主要与细胞凋亡、抗肿瘤等相关途径有关。结论ICA治疗OC与细胞生长抑制能力和细胞凋亡诱导能力显著相关,参与治疗作用的途径可能与细胞凋亡和抗肿瘤有关。
Objective To investigate the effect and possible mechanism of icariin(ICA)on ovarian cancer(OC).Methods Bioinformatics analysis was used to identify ICA targeted genes and OC related signaling pathways through network pharmacology.Cell experiments in PubMed,EMBASE,and Web of Science from June 2001 to June 2023 were retrieved to evaluate the effects of traditional ICA and placebo on OC,and the pathways and genes involved in the article were identified.Perform statistical analysis on the therapeutic targets mentioned in the literature.Results A total of 76 studies were retrieved,of which 8 had data that met the inclusion criteria.Analysis of the 14 successfully validated target genes revealed that they are mainly related to pathways such as cell apoptosis and anti-tumor effects.Conclusion ICA treatment for OC is significantly correlated with cell growth inhibition ability and apoptosis induction ability,and the pathways involved in the therapeutic effect may be related to cell apoptosis and anti-tumor effects.
作者
曹尚美
庄园
王薇
吴作敏
王韵旨
王瑞
付秀虹
CAO Shangmei;ZHUANG Yuan;WANG Wei;WU Zuomin;WANG Yunzhi;WANG Rui;FU Xiuhong(Luohe Central Hospital,Luohe 462000,Henan,China;The First Affiliated Hospital of Luohe Medical College,Luohe 462000,Henan,China;Henan Provincial Key Laboratory of Fertility Protection and Eugenics,Luohe 462000,Henan,China;Key Laboratory of Traditional Chinese Medicine Preparation and Processing in Henan Province,Luohe 462000,Henan,China;Henan Province Modern Technology Research and Clinical Application Engineering Research Center for Traditional Chinese Medicine Preparations,Luohe 462000,Henan,China)
出处
《中西医结合慢性病杂志》
2025年第1期11-17,共7页
JOURNAL OF INTEGRATED TRADITIONAL CHINESE AND WESTERN MEDICINE ON CHRONIC DISEASES
关键词
中医药
抗肿瘤
卵巢癌
网络药理学
淫羊藿苷
traditional Chinese medicine
anti-tumor
ovarian cancer
Network pharmacology
icariin
