摘要
胆囊癌是我国胆道系统最常见的恶性肿瘤,具有恶性程度高、手术切除率低、术后复发率高和放化疗不敏感等特点。改善胆囊癌预后,有赖于早期诊断、规范化的外科治疗和有效的综合治疗措施。这离不开深入开展胆囊癌的流行病学调查,以及探索肿瘤系统调控因素和微环境在胆囊癌发生、发展中的新机制。完善各期胆囊癌外科根治性切除范围和诊治流程,加强胆囊癌相关基础与临床转化研究,探索其生物学规律,有助于解决临床难题。
Gallbladder cancer(GBC)is the most common malignancy of the biliary system in China,characterized by high malignancy,low surgical resection rate,high postoperative recurrence,and poor responsiveness to chemotherapy and radiotherapy.Improving the prognosis of GBC relies on early diagnosis,standardized surgical treatment,and effective comprehensive therapeutic strate-gies.Achieving these goals necessitates in-depth epidemiological studies of GBC,as well as the exploration of new mechanisms involving systemic regulatory factors and the tumor microenviron-ment in the initiation and progression of GBC.It will help address the clinical challenges associated with this malignancy that improving the scope of surgical radical resection and diagnosis and treatment process for GBC in each stage and strengthening basic and translational research related to GBC to uncover its underlying biological principles.
作者
刘颖斌
陈炜
Liu Yingbin;Chen Wei(Department of Biliary-Pancreatic Surgery,Renji Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200127,China)
出处
《中华消化外科杂志》
北大核心
2025年第1期64-71,共8页
Chinese Journal of Digestive Surgery
基金
国家自然科学基金(3213000192)
上海市科委项目(23DZ2202800)。
关键词
胆囊肿瘤
外科手术
诊断
新辅助
基础研究
Gallbladder neoplasms
Surgical procedures,operative
Diagnosis
Neo-adjuvant
Basic research
