摘要
目的观察经验方“补肝利脂汤”对非酒精性脂肪肝的临床疗效,为实施“健康安康2030”战略提供科学数据及有效防治方案。方法选取符合纳排标准的非酒精性脂肪性肝炎患者151例,按随机数字表法分为治疗组1、治疗组2和对照组,治疗组1口服自拟“补肝利脂汤”,治疗组2口服水飞蓟宾,对照组无药物干预,所有患者均参加饮食运动调节,均检测并观察血脂7项、肝功能、瞬时弹性成像(Fibroscan)等的变化。结果甘油三酯(triglyceride,TG)分析:与对照组同期比较,治疗组1第24 w时间节点TG明显下降,有统计学差异(P<0.05);肝脏脂肪含量(Corrective Action Plan,CAP):与对照组同期比较,治疗组1、组2第24 w时间节点CAP下降明显,有统计学差异(P<0.05);谷丙转苷酶(Alanine aminotransferase,ALT):与对照组同期比较,治疗组1第12 w有明显差异(P<0.05),与对照组同期比较,治疗组1、组2第24 w时间节点均有明显差异(P<0.05);同期比较ALT在治疗组1、2之间、治疗组2的12 w与对照组均无明显差异(P>0.05)。结论“补肝利脂汤”有降低非酒精性脂肪肝患者甘油三酯水平、减轻肝脏炎症、降低转氨酶水平以及降低肝脏脂肪含量的作用;遵循三因治宜原则,以补肝气、升清降浊的中药防治干预,结合有氧运动、合理膳食、保证良好睡眠、根治幽门螺旋杆菌感染等方法可有效预防非酒精性脂肪肝带来的危害。
Objective To observe the clinical efficacy of the empirical formula“Bugan Lizhi Tang”on non-alcoholic fatty liver disease(NAFLD),and to provide scientific data and effective prevention and treatment programs for the implementation of the strategy of“Healthy Ankang 2030”.Methods 151 patients with non-alcoholic steatohepatitis satisfying the including and excluding criteria of NAFLD were selected and divided into three treatment groups,treantment group 1,treatment group 2 and controling group,according to the method of randomized numerical table.Treatment group 1 orally consumed the self-proposed“Bugan Lizhi Tang”,treatment group 2 orally consumed silymarin,and the control group did not have any pharmacological intervention.All the patients received the regulation of diet and exercise,and the changes of 7 items of blood lipids,liver function,and transient elastography(Fibroscan)were detected and observed.Results Triglyceride(TG)analysis:compared with controling group at the same time,TG level of treatment group 1 decreased significantly at the time point of 24th week,with statistical differences(P<0.05);result of liver fat content(Corrective Action Plan,CAP)analysis:compared with the controling group at the same time,CAP of treatment groups 1 and 2 decreased significantly at the time point of 24th week,with statistical differences(P<0.05);result of Alanine aminotransferase(ALT)analysis:compared with the controling group in the same period,there was a significant difference in the 12th week of treatment group 1(P<0.05),and there was a significant difference in the time node of 24th week of treatment group 1 and group 2(P<0.05);in terms of ALT level,there was no significant difference between the treatment group 1 and treatment group 2 at the same time,as well as the difference between the treatment group 2 and controling group at 12th week(P>0.05).Conclusion“Bugan Lizhi Tang”plays the vital roles of lowering triglyceride level,reducing liver inflammation,lowering aminotransferase level,and lowering liver fat content of patients with NAFLD.Under the guidance of the principle of“three-cause treatment”(adapt appropriate therapeutic measure depending on the season,place and patients personal constitution),the harm caused by NAFLD can be effectively prevented by using traditional Chinese medicine,which prevents,cures,and intervenes the progress of disease by tonifying the liver Qi,elevating essence and reducing turbidity,and based on this principle,combining with aerobic exercise,reasonable diet,good sleep,as well as eradicating Helicobacter pylori infection.
作者
程贤文
任信洁
詹艳荣
王振东
王峰
曾霞
施维群
时永全
杨涛
王新磊
刘遥顺
张博
万文雅
程贤英
张慧
朱希娅
宋娜
马梁
CHENG Xianwen;REN Xinjie;ZHAN Yanrong;WANG Zhendong;WANG Feng;ZENG Xia;SHI Weiqun;SHI Yongquan;YANG Tao;WANG Xinlei;LIU Yaoshun;ZHANG Bo;WAN Wenya;CHENG Xianying;ZHANG Hui;ZHU Xiya;SONG Na;MA Liang(Department of Gastroenterology,Ankang Traditional Chinese Medicine Hospital,Ankang 725000,China;First Clinical College of Shaanxi University of Chinese Medicine,Xianyang 712046,China;Second Clinical School of Zhejiang University of Chinese Medicine,Hangzhou 315000,China;Digestive Disease Hospital of the First Affiliated Hospital of Air Force Medical University,Xi'an 710000,China)
出处
《陕西中医药大学学报》
2025年第2期30-34,共5页
Journal of Shaanxi University of Chinese Medicine
基金
国家重点研发计划项目(2018YFC1344504)
陕西省科技厅一般项目(2023KJXX-111,2021FS-233)
陕西省中医药管理局课题(2021-ZZ-LC022)
安康市科技局课题(2018AK03-03)。
关键词
临床疗效
非酒精性脂肪肝
中医证候
补肝法
补肝利脂汤
clinical efficacy
non alcoholic fatty liver disease
traditional Chinese medicine syndrome
liver tonifying method
Bugan Lizhi Tang
