靶向髓源性抑制细胞在肺癌免疫治疗中的应用前景及进展

导出

摘要髓源性抑制细胞(Myeloid-derived suppressor cells,MDSCs)具有强大的免疫抑制能力,是肿瘤微环境中主要的负调控细胞之一。越来越多的证据表明MDSCs在肺癌的形成和进展中起着重要作用。本文综述了MDSCs在肺肿瘤微环境中的多重作用,以及MDSCs与预后不良和免疫治疗耐药的内在关联,探讨了靶向MDSCs在肺癌免疫治疗中的策略及前景。

作者李娇张春阳韩志海

机构地区解放军总医院第六医学中心呼吸与危重症医学科安徽医科大学第五临床医学院海军临床学院

出处《临床肺科杂志》 2025年第3期454-462,共9页 Journal of Clinical Pulmonary Medicine

基金北京市自然科学基金(7232169)。

关键词髓源性抑制细胞肺癌免疫治疗

分类号 R734.2 [医药卫生—肿瘤]

引文网络
相关文献

参考文献6

1Yuefei Zhu,Xiangrong Yu,Soracha D.Thamphiwatana,Ying Zheng,Zhiqing Pang.Nanomedicines modulating tumor immunosuppressive cells to enhance cancer immunotherapy[J].Acta Pharmaceutica Sinica B,2020,10(11):2054-2074. 被引量：18
2Yijia Tang,Guangzu Cui,Haicong Liu,Ying Han,Changjing Cai,Ziyang Feng,Hong Shen,Shan Zeng.Converting“cold”to“hot”:epigenetics strategies to improve immune therapy effect by regulating tumor-associated immune suppressive cells[J].Cancer Communications,2024,44(6):601-636. 被引量：7
3LIU Wen,WU Tian-Cong,HONG Dong-Mei,HU Yue,FAN Ting,GUO Wen-Jie,XU Qiang.Carnosic acid enhances the anti-lung cancer effect of cisplatin by inhibiting myeloid-derived suppressor cells[J].Chinese Journal of Natural Medicines,2018,16(12):907-915. 被引量：14
4Saeed Daneshmandi,Qi Yan,Jee Eun Choi,Eriko Katsuta,Cameron R.MacDonald,Mounika Goruganthu,Nathan Roberts,Elizabeth A.Repasky,Prashant K.Singh,Kristopher Attwood,Jianmin Wang,Yosef Landesman,Philip L.McCarthy,Hemn Mohammadpour.Exportin 1 governs the immunosuppressive functions of myeloid-derived suppressor cells in tumors through ERK1/2 nuclear export[J].Cellular & Molecular Immunology,2024,21(8):873-891. 被引量：1
5Shu-Chang Nie,Yan-Hua Jing,Lu Lu,Si-Si Ren,Guang Ji,Han-Chen Xu.Mechanisms of myeloid-derived suppressor cell-mediated immunosuppression in colorectal cancer and related therapies[J].World Journal of Gastrointestinal Oncology,2024,16(5):1690-1704. 被引量：2
6Kyohei Nakamura,Mark J.Smyth.Myeloid immunosuppression and immune checkpoints in the tumor microenvironment[J].Cellular & Molecular Immunology,2020,17(1):1-12. 被引量：50

二级参考文献23

1Yu Fu,Qing Lin,Zhirong Zhang,Ling Zhang.Therapeutic strategies for the costimulatory molecule OX40 in T-cell-mediated immunity[J].Acta Pharmaceutica Sinica B,2020,10(3):414-433. 被引量：28
2Xi Zhang,Hong Wen,Xiaobing Shi.Lysine methylation： beyond histones[J].Acta Biochimica et Biophysica Sinica,2012,44(1):14-27. 被引量：9
3LIU Wen,WU Tian-Cong,HONG Dong-Mei,HU Yue,FAN Ting,GUO Wen-Jie,XU Qiang.Carnosic acid enhances the anti-lung cancer effect of cisplatin by inhibiting myeloid-derived suppressor cells[J].Chinese Journal of Natural Medicines,2018,16(12):907-915. 被引量：14
4Yuan Yin,Xing Cai,Xi Chen,Hongwei Liang,Yujing Zhang,Jing Li,Zuoyun Wang,Xiulan Chen,Wen Zhang,Seiji Yokoyama,Cheng Wang,Liang Li,Limin Li,Dongxia Hou,Lei Dong,Tao Xu,Takachika Hiroi,Fuquan Yang,Hongbin Ji,Junfeng Zhang,Ke Zen,Chen-Yu Zhang.Tumor-secreted miR-214 induces regulatory T cells： a major link between immune evasion and tumor growth[J].Cell Research,2014,24(10):1164-1180. 被引量：37
5Wenbin Li,Xinghua Zhang,Yongkang Chen,Yibin Xie,Jiancheng Liu,Qiang Feng,Yi Wang,Wei Yuan,Jie Ma.G-CSF is a key modulator of MDSC and could be a potential therapeutic target in colitis-associated colorectal cancers[J].Protein & Cell,2016,7(2):130-140. 被引量：32
6刘艳芳,顾炎,韩岩梅,张迁,蒋正平,张相,黄波,许小青,郑建明,曹雪涛.肿瘤来源外泌体通过激活肺上皮细胞TLR3促进肺转移前微环境形成[J].中国肿瘤生物治疗杂志,2017,24(1). 被引量：44
7Atsushi Tanaka,Shimon Sakaguchi.Regulatory T cells in cancer immunotherapy[J].Cell Research,2017,27(1):109-118. 被引量：154
8LU Yu-tong,LI Jie,QI Xin,PEI Ying-xia,SHI Wen-guang,LIN Hong-sheng.Effects of Shugan Jianpi Formula(疏肝健脾方)on Myeloid-Derived Suppression Cells-Mediated Depression Breast Cancer Mice[J].Chinese Journal of Integrative Medicine,2017,23(6):453-460. 被引量：8
9Kyohei Nakamura,Mark J. Smyth.Aberrant erythropoiesis fuels tumor growth[J].Cell Research,2018,28(6):611-612. 被引量：1
10Sandra Wagner,Christina S Mullins,Michael Linnebacher.Colorectal cancer vaccines: Tumor-associated antigens vs neoantigens[J].World Journal of Gastroenterology,2018,24(48):5418-5432. 被引量：17

共引文献85

1陈华蕾,李威.原发性肝癌治疗中索拉非尼耐药发生机制的研究进展[J].肿瘤,2021,41(6):435-443. 被引量：9
2Huile Gao,Zhiqing Pang,Wei He.Editorial of Special Issue on Tumor Microenvironment and Drug Delivery[J].Acta Pharmaceutica Sinica B,2020,10(11):2016-2017.
3雷文静,陆菲,米文娟,查定军.银杏叶提取物保护顺铂致小鼠HEI-OC1细胞损伤的作用及机制研究[J].听力学及言语疾病杂志,2019,27(5):519-523. 被引量：6
4赵昕.鼠尾草酸对煎炸条件下玉米油品质裂变的影响[J].粮食与油脂,2020,33(3):65-69. 被引量：1
5邓祥敏,阮仁余,朱星宇,李光.鼠尾草酸的生物活性研究进展[J].现代中西医结合杂志,2020,29(10):1137-1140. 被引量：2
6刘永华,江锦红,朱亭郡,陈佳琪,王朋,兰义芬,周泽平,汪笑秋,章俏雷,王晓丽,金伟媚,曾玉晓,江妤,林煌,方炳木.髓系来源抑制细胞在多发性骨髓瘤患者中的外周血表达与临床效果观察[J].中国临床实用医学,2020,11(1):2-5. 被引量：1
7CHEN Yu-Chi,HUANG Mu-Yang,ZHANG Le-Le,FENG Zhe-Ling,JIANG Xiao-Ming,YUAN Luo-Wei,HUANG Run-Yue,LIU Bo,YU Hua,WANG Yi-Tao,CHEN Xiu-Ping,LIN Li-Gen,LU Jin-Jian.Nagilactone E increases PD-L1 expression through activation of c-Jun in lung cancer cells[J].Chinese Journal of Natural Medicines,2020,18(7):517-525. 被引量：6
8卜国峰,修子超,邵翠华,孙立江,荆涛,王沛涛.影响阴茎癌患者术后预后危险因素的研究[J].临床泌尿外科杂志,2020(6):426-430. 被引量：5
9许军英,廖原,冯叶叶,王小芳,陈雪玲.CD11b+细胞诱导CD8+T细胞表达PD-1研究[J].石河子大学学报（自然科学版）,2020,38(4):502-506.
10姬颖华,杨晓煜,孟祥丽,王瑾,路平.氧化苦参碱通过下调程序性细胞死亡1蛋白表达逆转顺铂耐药非小细胞肺癌细胞A549/Cis的顺铂耐药性[J].中国药理学与毒理学杂志,2020,34(10):743-749. 被引量：7

1张琦君,冯丽娜,李玉琴,邓海滨,沈欢,殷书敏,徐振晔.肺岩宁方对老年非小细胞癌患者癌因性疲乏及T淋巴细胞、MDSCs、Tregs水平的影响[J].西部中医药,2025,38(1):43-48. 被引量：1
2Dong-Liang Chen,Nuo Chen,Hui Sheng,Dong-Sheng Zhang.Circular RNA circNCOA3 promotes tumor progression and anti-PD-1 resistance in colorectal cancer[J].Cancer Drug Resistance,2024,7(1):925-939.
3陈玉梅,戴锦东,张一珂,李泽兰,朱栋炜,朱成栋.工程化的PMN-MDSCs来源外泌体在胶原诱导性关节炎小鼠中的应用[J].江苏大学学报(医学版),2025,35(1):1-7.
4张岩,汪玉龙,白泽通,郭岩松,李琳,邵将,王岩,郑克彬.骨髓源性抑制细胞与胶质母细胞瘤细胞代谢之间关系的研究进展[J].现代肿瘤医学,2025,33(3):501-508.
5张浩,管静芝.贫血对肿瘤免疫反应的影响及机制研究[J].解放军医学院学报,2024,45(11):1134-1145.
6Ryan A.Lacinski,Sebastian A.Dziadowicz,Vincent K.Melemai,Brody Fitzpatrick,John J.Pisquiy,Tanya Heim,Ines Lohse,Karen E.Schoedel,Nicolas J.Llosa,Kurt R.Weiss,Brock A.Lindsey.Spatial multiplexed immunofluorescence analysis reveals coordinated cellular networks associated with overall survival in metastatic osteosarcoma[J].Bone Research,2024,12(4):877-894. 被引量：4
7廖新月,冯燕,余丽.肿瘤微环境中免疫细胞在口腔鳞状细胞癌发生发展中作用的研究进展[J].口腔疾病防治,2025,33(2):160-168. 被引量：1
8李梦瑶,花东明,王志燕,刘芝亦,龚航军,孙云川,呼雪庆,王炎.蛋白激酶AURKA介导的大肠癌肿瘤微环境特征及中药有效成分挖掘[J].四川大学学报(医学版),2025,56(1):59-67.
9唐文韬(综述),李丹(审校).髓样抑制细胞促进坐骨神经的损伤后修复[J].河北医科大学学报,2025,46(2):241-248.

临床肺科杂志

2025年第3期

浏览历史

内容加载中请稍等...

靶向髓源性抑制细胞在肺癌免疫治疗中的应用前景及进展

参考文献6

二级参考文献23

共引文献85

相关作者

相关机构

相关主题

浏览历史