摘要
目的 评估宫腔镜子宫内膜息肉切除术(transcervical resection of polyp,TCRP)联合地屈孕酮治疗子宫内膜息肉(endometrial polyp,EP)的疗效及其对患者预后的影响。方法 选取2022年6月—2023年12月毕节市第二人民医院收治的60例EP患者作为研究对象,按照不同治疗方法分为观察组和对照组,每组30例。两组患者均接受TCRP治疗,对照组在术后接受甲羟孕酮治疗,观察组在对照组基础上增加地屈孕酮治疗。对比两组子宫内膜厚度、月经量、血红蛋白、子宫内膜血流阻力指数、子宫异常出血率和EP复发率。结果 与术后6个月相比,术后12个月两组患者的子宫内膜厚度与月经量均降低,且观察组低于对照组,差异有统计学意义(P均<0.05)。与术后6个月相比,术后12个月两组患者血红蛋白均升高,子宫内膜血流阻力指数均降低,且观察组改善幅度优于对照组,差异有统计学意义(P均<0.05)。术后12个月,观察组子宫异常出血发生率为6.67%(2/30),子宫内膜息肉复发率为3.33%(1/30),低于对照组的30.00%(9/30)、20.00%(6/30),差异有统计学意义(χ^(2)=5.455、4.043,P均<0.05)。结论 TCRP联合地屈孕酮治疗子宫内膜息肉,能更有效地降低子宫内膜厚度和月经量,提高血红蛋白水平,降低子宫内膜血流阻力指数,减少子宫异常出血率和EP复发率,从而改善患者的预后。
Objective To evaluate the efficacy of transcervical resection of polyp(TCRP) combined with dydrogesterone in the treatment of endometrial polyp(EP) and its effect on the prognosis of patients.Methods Sixty patients with EP admitted to the Second People's Hospital of Bijie City from June 2022 to December 2023were selected as the study subjects.According to different treatment methods,they were divided into observation group and control group,with 30 cases in each group.Both groups of patients received TCRP treatment,the control group received medroxyprogesterone treatment after surgery,and the observation group received dydrogesterone treatment on the basis of the control group.The endometrial thickness,menstrual volume,hemoglobin,endometrial blood flow resistance index,abnormal uterine bleeding rate and recurrence rate EP were compared between the two groups.Results Compared with 6 months after operation,the endometrial thickness and menstrual volume of the two groups decreased at 12 months after operation,and the observation group was lower than the control group,the differences were statistically significant(both P<0.05).Compared with 6 months after operation,12 months after operation,the hemoglobin of the two groups increased and endometrial blood flow resistance index decreased,and the improvement of the observation group was better than that of the control group,the differences were statistically significant(both P<0.05).At 12 months after operation,the abnormal uterine bleeding rate in the observation group was 6.67%(2/30),and the recurrence rate of EP was 3.33%(1/30),which were lower than 30.00%(9/30) and 20.00%(6/30) in the control group,the differences were statistically significant(χ~2=5.455,4.043,both P<0.05).Conclusion TCRP combined with dydrogesterone in the treatment of EP can more effectively reduce endometrial thickness and menstrual volume,increase hemoglobin level,reduce endometrial blood flow resistance index,reduce abnormal uterine bleeding rate and recurrence rate of EP,thereby improving the prognosis of patients.
作者
李婷
赵丽琴
陈翛
LI Ting;ZHAO Liqin;CHEN Xiao(Department of Obstetrics and Gynecology,the Second People's Hospital of Bijie City,Bijie 551700,Guizhou,China)
出处
《世界复合医学(中英文)》
2024年第10期107-110,154,共5页
World Journal of Complex Medicine
