摘要
目的探索近20年来基于我国中医药治疗脑缺血机制的发展趋势和研究热点,为未来的研究方向提供参考。方法检索中国知网2000年1月1日至2023年6月1日,基于中医药治疗脑缺血机制相关国内文献,分析自噬和血管新生相关的脑缺血机制文献。结果共收录3346篇文献。年度发表文献数量呈持续增长趋势。机构合作网络图谱涉及654所机构,以中医药类大学或研究所为主。脑缺血机制相关的研究热点主要集中于凋亡、炎症、氧化应激、自噬和血管新生等机制,研究对象有血脑屏障、海马、线粒体、神经元等,研究手段针刺、中药等。结论国内脑缺血机制研究在过去20年中稳步发展,且大多数研究在中医药领域,下一步应对治疗脑缺血的优势中医药物进行临床和循证医学分析,找到优势组方和经典药物,为中医药治疗脑缺血的相关研究提供参考。
Objective To explore the developments and research hotspots in the field of cerebral ischemia mechanisms in China over the past two decades in order to provide references for future research.Methods Domestic literature related to cerebral ischemia mechanisms published by China National Knowledge Infrastructure(CNKI)between January 1,2000 and June 1,2023 was retrieved while other literature on cerebral ischemia mechanisms related to autophagy and angiogenesis was analyzed.Results A total of 3346 articles were included.The annual number of publications trended upward.The network diagram of institutional cooperation involved 654 institutions,most of which were traditional Chinese medicine universities or research institutes.Research related to the mechanism of cerebral ischemia revolved around such mechanisms as apoptosis,inflammation,oxidative stress,autophagy and angiogenesis.The targets of study included the blood-brain barrier,hippocampus,mitochondria,and neurons while research methods involved acupuncture and traditional Chinese medicine.Conclusion The research on the mechanism of cerebral ischemia in China has made steady progress in the past 20 years,and most of the research focuses on traditional Chinese medicine.The next step should be clinical and evidence-based analysis of superior traditional Chinese medicine drugs for the treatment of cerebral ischemia,and identify superior prescriptions and classic drugs so as to provide references for research on the treatment of cerebral ischemia by traditional Chinese medicine.
作者
郑恩琪
白雪
ZHENG Enqi;BAI Xue(Experimental Research Center,China Academy of Chinese Medical Sciences,Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment of Major Disease,Beijing 100700,China;Faculty of Medicine and Health,University of Sydney,Sydney NSW,Australia)
出处
《中国药物警戒》
2024年第12期1398-1404,共7页
Chinese Journal of Pharmacovigilance
基金
国家自然科学基金资助项目(82304767)
中央级公益性科研院所基本科研业务费专项基金(JJPY2022021、ZZ15-YQ-055)
中国中医科学院科技创新工程项目(CI2021B017)
中国中医科学院西苑医院院级师承项目(YJMPSC202437)。
关键词
脑缺血
机制
自噬
血管新生
凋亡
炎症
氧化应激
中医药
Cerebral Ischemia
Mechanism
Autophagy
Angiogenesis
Apoptosis
Inflammation
Oxidative Stress
Traditional Chinese Medicine
