摘要
目的:探讨胎盘生长因子(PLGF)、可溶性血管内皮生长因子受体(sFlt-1)及胎盘CD146表达与子痫前期(PE)及其胎儿生长受限(FGR)关系。方法:选取2022年9月-2024年4月本院就诊的PE并发FGR孕妇60例为FGR组,PE非FGR孕妇60例为非FGR组,健康孕妇60例作为健康组,比较各组血清PLGF、sFlt-1水平及胎盘CD146表达差异。结果:FGR组血清PLGF(150.20±33.34pg/ml)和胎盘CD146阳性表达率(23.3%)均低于非FGR组和健康组,而sFlt-1(2640.40±113.43ng/L)高于非FGR组和健康组(均P<0.05)。FGR组重度PE孕妇血清PLGF(142.01±35.52pg/ml)和胎盘CD146阳性表达率(11.6%)低于轻度PE孕妇,sFlt-1(2718.91±121.16ng/L)高于轻度PE孕妇(P<0.05);非FGR组重度PE孕妇血清PLGF(206.81±50.11pg/ml)和胎盘CD146阳性表达率(38.2%)低于轻度PE孕妇,sFlt-1(2327.90±110.10ng/L)高于轻度PE孕妇(均P<0.05)。受试者工作特征曲线分析,血清PLGF、sFlt-1水平预测PE孕妇发生FGR的曲线下面积分别为0.927和0.855(P<0.05)。结论:血清PLGF、sFlt-1水平及胎盘CD146表达与PE及其病情以及FGR有关,且血清PLGF、sFlt-1水平对预测PE孕妇发生FGR有较高价值。
Objective: To explore the correlation between the levels of serum placental growth factor(PLGF) and soluble vascular endothelial growth factor receptor(sFlt-1), and the placental CD146 expression of pregnant women with preeclampsia and their fetal growth restriction(FGR). Methods: 60 pregnant women with preeclampsia and FGR who visited the hospital were selected in group A, while 60 pregnant women with preeclampsia and without FGR were selected in group B and 60 healthy pregnant women were selected in group C from September 2022 to April 2024. The serum PLGF and sFlt-1 levels, and the difference of the placental CD146 expression of the women were compared among the three groups. Results: The levels of serum PLGF(150.20±33.34pg/ml) and the placental CD146 positive expression rate(23.3%) of the women in group A were significantly lower than those of the women in group B or in group C, while the serum sFlt-1 level(2640.40±113.43ng/L) of the women in group A was significantly higher than that of the women in group B or in group C(all P<0.05). In group A, the serum PLGF level(142.01±35.52pg/ml) and the positive expression rate of placental CD146(11.6%) of the women with severe PE were significantly lower than those of the women with mild PE, and the sFlt-1 level(2718.91±121.16ng/L) of the women with severe PE was significantly higher than that of the women with mild PE(P<0.05). In group B, the serum PLGF(206.81±50.11pg/ml) and the positive expression rate of placental CD146(38.2%) of the women with severe PE women were significantly lower than those of the women with mild PE, and the sFlt-1 level(2327.90±110.10ng/L) of the women with severe PE women was significantly higher than that of the women with mild PE women(all P<0.05).Receiver operating characteristic(ROC)curve analysis showed that the area under the curve of the serum PLGF and sFlt-1levels of the pregnant women with PE for predicting their FGR were 0.927and 0.855(P<0.05).Conclusion:The levels of serum PLGF and sFlt-1,and the placental CD146expression of the pregnant women are associated with their preeclampsia occurrence and the severity of preeclampsia,as well as their FGR occurrence.The levels of the serum PLGF and sFlt-1of the pregnant women with PE have higher predictive value for their FGR occurrence.
作者
丁盈
于复洲
DING Ying;YU Fuzhou(Jiaxing Maternal and Child Health Care Hospital,Zhejiang Province,Zhejiang Province,314000)
出处
《中国计划生育学杂志》
2025年第2期419-424,共6页
Chinese Journal of Family Planning
关键词
子痫前期
病情程度
胎儿生长受限
胎盘生长因子
可溶性血管内皮生长因子受体
胎盘CD146表达
预测
Preeclampsia
Severity
Fetal growth restriction
Placental growth factor
Soluble vascular endothelial growth factor receptor
Expression of CD146 in placenta
Prediction
