摘要
To the Editor:Traumatic brain injury(TBI)is a life-threatening condition and global public health concern in both developed and developing countries.[1]During the last few decades,the morbidity and mortality associated with TBI have decreased.However,the precise mechanisms that contribute to the outcomes remain unclear.Recently,researchers have become aware that owing to the brain–gut axis interaction,the central nervous system is closely related to the gut microbiota.[2]Many studies have correlated the gut microbiota and its metabolites with autism,depression,stroke,and Parkinson’s disease.[3]Whether changes in the gut microbial composition affect TBI remains largely unknown.Metabolomics,a method focuses on deriving a comprehensive analysis of low-molecular-weight endogenous metabolites in biofluids or tissues and has been used to explore metabolic changes in a variety of diseases.However,the relationship between the metabolome and TBI outcomes or progression and the relationship between the gut microbiome and TBI remain unclear.Hence,we compared the gut microbiome and serum metabolome of patients with TBI and healthy individuals to identify specific bacterial and serum metabolome differences.
基金
supported by grants from National Natural Science Foundation of China(No.82202438)
Clinical and Translational Research Project of Anhui Province(No.202427b10020130)
Beijing Postdoctoral Foundation(No.2020-ZZ-008)
Returned overseas students from Anhui Province in 2020 Innovation and Entrepreneurship Support Plan Project(No.2020LCX016)
Funding of The Anhui Universal Natural Science Foundation(No.KJ2020A0172)
Cultivate Funding of the National Natural Science Foundation of China(No.2016KJ12).
