摘要
目的探讨青年慢性萎缩性胃炎的危险因素。方法选取2011年1月至2021年12月南方医科大学南方医院消化内科内镜中心诊治的2394例青年慢性胃炎患者作为研究对象,其中慢性萎缩性胃炎286例(萎缩组),慢性非萎缩性胃炎1976例(非萎缩组)。回顾性收集患者的一般资料及临床资料,确定慢性萎缩性胃炎发生及中重度萎缩性胃炎的独立危险因素。结果年龄、幽门螺杆菌(Helicobacter pylori,H.pylori)感染、饮酒史、胃癌家族史、抑郁、焦虑及高盐饮食与慢性萎缩性胃炎发生风险呈相关(P<0.05);两组间的身体质量指数(body mass index,BMI)、性别、吸烟史、受教育程度及经济收入均无统计学差异(P>0.05);多因素Logistic回归分析显示,年龄、H.pylori感染、饮酒史、焦虑情绪、高盐饮食和胃癌家族史是发生慢性萎缩性胃炎的独立危险因素。在中重度萎缩的慢性萎缩性胃炎患者中,男性、H.pylori感染、吸烟史、胃癌家族史、抑郁、焦虑的比例显著高于轻度萎缩患者的比例(P均<0.05);多因素Logistic回归分析显示,男性、H.pylori感染、吸烟者和焦虑情绪、胃癌家族史是加重胃黏膜萎缩程度的独立危险因素。结论年龄、H.pylori感染、饮酒、焦虑情绪、高盐饮食和胃癌家族史为青年患者罹患慢性萎缩性胃炎的独立危险因素。男性、H.pylori感染、吸烟史、存在焦虑情绪以及胃癌家族史为青年慢性萎缩性胃炎患者发展为中重度萎缩的独立危险因素。
Objective To investigate the risk factors for chronic atrophic gastritis in young adults.Methods A total of 2,394 young adult patients diagnosed with chronic gastritis at the Endoscopy Center of the Department of Gastroenterology,Nanfang Hospital,Southern Medical University,between January 2011 and December 2021,were retrospectively studied.Among them,286 cases were identified as chronic atrophic gastritis(atrophy group),and 1,976 cases were classified as chronic non-atrophic gastritis(non-atrophy group).General and clinical data were collected and analyzed to identify the independent risk factors for chronic atrophic gastritis.Independent risk factors for moderate-to-severe atrophy were also analyzed.Results Factors such as age,Helicobacter pylori(H.pylori)infection,alcohol consumption,family history of gastric cancer,depression,anxiety,and high-salt diet were significantly associated with an increased risk of chronic atrophic gastritis(P<0.05).No statistically significant differences were found in body mass index(BMI),gender,smoking status,education level,or economic income between the two groups(P>0.05).Multivariate logistic regression analysis revealed that age,H.pylori infection,alcohol consumption,anxiety,high-salt diet,and family history of gastric cancer were independent risk factors for the development of chronic atrophic gastritis.In patients with moderate-to-severe atrophy,the proportions of males,H.pylori infection,smokers,family history of gastric cancer,depression,and anxiety were significantly higher compared to patients with mild atrophy(all P<0.05).Multivariate logistic regression analysis showed that male gender,H.pylori infection,smoking,anxiety,and family history of gastric cancer were independent risk factors for the progression of gastric mucosal atrophy.Conclusion Age,H.pylori infection,alcohol consumption,anxiety,high-salt diet,and family history of gastric cancer are independent risks factors for young patients developing chronic atrophic gastritis.Male gender,H.pylori infection,smoking history,anxiety,and family history of gastric cancer are independent risks factors for the progression of chronic atrophic gastritis in young patients from moderate to severe atrophy.
作者
方霖
白杨
张亚历
FANG Lin;BAI Yang;ZHANG Yalig(Department of Gastroenterology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China)
出处
《现代消化及介入诊疗》
2024年第11期1300-1303,1308,共5页
Modern Interventional Diagnosis and Treatment in Gastroenterology
基金
广东省科技计划项目(2017B030314037)。
关键词
青年人
慢性萎缩性胃炎
危险因素
中重度萎缩
Young adults
Chronic atrophic gastritis
Risk factors
Moderate-to-severe atrophy
