摘要
目的 基于五脏相音理论研究帕金森病(PD)患者的五音特征,为PD的早期诊断及辨证施治提供依据。方法 收集PD患者272例作为帕金森病组,并招募患者家属及医院工作人员240例作为对照组。运用二十五音分析仪采集PD患者和对照组受试者五音特征,再将两组受试者按性别和41~55岁、56~70岁、71~85岁三个年龄段进行分层,比较两组受试者的五音频次和构成比,并计算每位患者平均声音频率,比较两组受试者声音频率的差异。结果 41~55岁、56~70岁年龄段男性帕金森病组和对照组受试者均是羽音频次最高,且帕金森病组羽音构成比均较对照组高(P<0.05);56~70岁年龄段男性帕金森病组受试者商音、徵音构成比较对照组低(P<0.05);71~85岁年龄段男性帕金森病组和对照组受试者均以羽音频次最高,两组的五音构成比比较差异无统计学意义(P>0.05)。各年龄段女性帕金森病组受试者均是羽音频次最高,而各年龄段女性对照组均是角音频次最高,且各年龄段女性帕金森病组羽音构成比均较对照组高(P<0.05);56~70岁帕金森病组女性角音构成比低于对照组(P<0.05)。帕金森病组男性41~55岁、56~70岁年龄段的声音频率高于相同年龄段对照组,帕金森病组女性56~70岁、71~85岁声音频率高于相同年龄段对照组(P<0.05)。结论 PD患者嗓音呈现频率升高、五音中羽音构成比增高的特征,提示患者多存在肾精亏虚的病机,可为PD的早期诊断及辨证施治提供参考。
Objective To study the characteristics of the five tones of Parkinson's disease(PD)patients based on the theory of"five-viscera phonology",and provide references for the syndrome differentiation and treatment of PD.Methods A total of 272 cases of PD patients were collected as the PD group,and 240 individuals,including patient family members and hospital staff,were recruited as the control group.The 25-tone analyzer was used to collect the five-tone characteristics of both PD patients and control group participants.The participants were then stratified into three age groups,41~55,56~70,and 71~85 years old,and categorized by gender(male and female)for analysis.The frequency and composition ratio of the five tones were analyzed for both groups across the different age ranges and genders.Additionally,the average voice frequency of each participant was calculated to compare differences between groups,stratified by age range and gender.Results In the 41~55 and 56~70 age groups,male participants in the PD group and the control group exhibited the highest frequency of Yu(羽)tone,with the PD group showing a significantly higher composition ratio of Yu tone compared to the control group(P<0.05);for males in the 56~70 age group,the composition ratios of Shang(商)and Zhi(徵)tone in the PD group were lower than those in the control group(P<0.05).For males in the 71~85 age group,both the PD group and the control group had the highest frequency of Yu tone,but there was no statistically significant difference in the composition ratios of the five tones between groups(P>0.05).For female participants in the PD group across all age groups,Yu tone was the most frequent,whereas for the control group,Jue(角)tone was the most frequent in all age groups,and the composition ratio of Yu tone in the PD group was significantly higher than that in the control group across all age groups(P<0.05);in the 56~70 age group,the composition ratio of Jue tone was lower in the PD group compared to that in the control group(P<0.05).Regarding voice frequency,males in the PD group aged 41~55 and 56~70 had higher voice frequency than those in the control group of the same age range,and similarly,females in the PD group aged 56~70 and 71~85 had higher voice frequency than their counterparts in the control group(P<0.05).Conclusion PD patients have a voice with a higher frequency and an increased proportion of Yu tone in their five-tone distribution.According to the theory of five-viscera phonology,PD patients may have disease mechanism of kidney essence deficiency.
作者
杨文学
王学林
李敏
李绍旦
杨明会
Yang Wenxue;WANG Xuelin;LI Min;LI Shaodan;YANG Minghui(Department of Traditional Chinese Medicine,the Sixth Medical Centre,the People's Liberation Army General Hospital and Medical School,Beijing,100853;0ingdao Navy Special Recreation Centre)
出处
《中医杂志》
北大核心
2025年第2期165-169,共5页
Journal of Traditional Chinese Medicine
基金
国家自然科学基金(82130117)。
关键词
帕金森病
五脏相音
肾精亏虚
羽音
病例对照研究
Parkinson's disease
five-viscera phonology
deficiency of kidney essence
Yu(羽)tone
case-control study
