摘要
目的探讨孕期不同环境细颗粒物(fine particulate matter,PM_(2.5))暴露与孕妇碘营养水平之间是否存在关联。方法2023年3-8月,采用病例-对照研究方法,分别选择PM_(2.5)污染较为严重的乌鲁木齐市米东区和空气质量指数较高的博尔塔拉蒙古自治州博乐市作为调查地点,在上述地点选择自愿参与本研究且符合纳入、排除标准的孕28周之前孕妇作为研究对象。以问卷形式调查研究对象基本信息;采集研究对象全血、唾液、尿液样本,检测血清碘、唾液碘、尿碘、尿肌酐水平;并分别计算米东区和博乐市孕妇室外、室内、多重环境日均PM_(2.5)暴露浓度。通过广义线性模型分析孕期不同环境PM_(2.5)暴露浓度与孕妇碘营养水平的关联。结果米东区纳入157名孕妇,博乐市纳入145名孕妇。两地区孕妇室外日均PM_(2.5)暴露浓度、室内日均PM_(2.5)暴露浓度、多重环境日均最高PM_(2.5)暴露浓度和多重环境日均最低PM_(2.5)暴露浓度比较,差异均有统计学意义(均P<0.05);两地区孕妇血清碘[M(Q_(1),Q_(3)):83.99(71.93,93.39)、86.93(76.90,98.31)μg/L]和唾液碘水平[76.90(44.93,140.36)、50.22(24.12,82.77)μg/L]比较,差异均有统计学意义(均P<0.05)。米东区和博乐市整体孕妇室内、室外日均PM_(2.5)暴露浓度与唾液碘水平均呈正相关(均P<0.001),多重环境日均最低PM_(2.5)暴露浓度与血清碘水平呈正相关(P=0.019)。结论不同PM_(2.5)暴露地区孕妇碘营养水平存在差异,孕期不同环境PM_(2.5)暴露可能导致孕妇碘营养水平波动。
Objective To investigate whether there is an correlation between exposure to fine particulate matter(PM_(2.5))in different environments during pregnancy and iodine nutritional levels of pregnant women.Methods From March to August 2023,a case-control study method was used to select Midong District of Urumqi City with severe PM_(2.5)pollution and Bole City of Bortala Mongolian Autonomous Prefecture with higher air quality index as the survey sites.Pregnant women before 28 weeks of pregnancy who voluntarily participated in this study and met the inclusion and exclusion criteria,were selected as the study subjects at the above locations.The basic information of the study subjects was investigated in the form of questionnaires.Whole blood,saliva,and urine samples were collected from the study subjects to determine serum iodine,salivary iodine,urinary iodine,and urinary creatinine levels.The average daily PM_(2.5)exposure concentrations of pregnant women in outdoor,indoor,and multiple environments were calculated in Midong District and Bole City,respectively.The correlation between PM_(2.5)exposure concentrations in different environments during pregnancy and iodine nutrition level of pregnant women was analyzed through a generalized linear model.Results Midong District included 157 pregnant women,and Bole City included 145 pregnant women.There were statistically significant differences in the outdoor daily average PM_(2.5)exposure concentration,indoor daily average PM_(2.5)exposure concentration,daily maximum PM_(2.5)exposure concentration in multiple environments,and daily minimum PM_(2.5)exposure concentration in multiple environments among pregnant women between the two regions(P<0.05).The serum iodine[M(Q_(1),Q_(3)):83.99(71.93,93.39),86.93(76.90,98.31)μg/L]and salivary iodine levels[76.90(44.93,140.36),50.22(24.12,82.77)μg/L]of pregnant women in the two regions were compared,and the differences were statistically significant(P<0.05).The overall indoor and outdoor daily average PM_(2.5)exposure concentrations of pregnant women in Midong District and Bole City were positively correlated with salivary iodine levels(P<0.001),and the daily minimum PM_(2.5)exposure concentration in multiple environments was positively correlated with serum iodine levels(P=0.019).Conclusion There are differences in iodine nutrition levels among pregnant women in different PM_(2.5)exposure areas,and exposure to PM_(2.5)during pregnancy may lead to fluctuations in iodine nutrition levels among pregnant women.
作者
周婧
王昌
付若楠
丹尼尔·阿不都外力
日沙来提·塔依尔
张玲
王琛琛
Zhou Jing;Wang Chang;Fu Ruonan;Dannier Abuduwaili;Rishalaiti Tayier;Zhang Ling;Wang Chenchen(School of Public Health,Xinjiang Medical University,Urumqi 830054,China;Institute of Health Hazard Factors Monitoring and Control,Xinjiang Uygur Autonomous Regional Center for Disease Control and Prevention,Urumqi 830002,China)
出处
《中华地方病学杂志》
北大核心
2024年第12期947-953,共7页
Chinese Journal of Endemiology
基金
国家自然科学基金(82260648)
关键词
孕妇
孕早期
细颗粒物
碘营养水平
母婴健康
Pregnant women
Early pregnancy
Fine particulate matter
Iodine nutrition level
Maternal and infant health
