摘要
目的 分析H型高血压合并急性缺血性脑卒中(AIS)患者同型半胱氨酸(Hcy)水平变化及预后的影响因素。方法 选择2019年4月至2021年4月期间医院收治的260例H型高血压患者,其中,H型高血压合并AIS患者125例(A组)、单纯H型高血压患者135例(B组)。A组按预后分为预后良好组(69例)与预后不良组(56例)两个亚组。选取同期在医院门诊行体格检查的健康人员100例(对照组)。所有患者均给予常规治疗,对H型高血压合并AIS患者预后进行单因素和Logistic多种因素回归分析。结果 A组、B组血清Hcy水平均明显高于对照组,A组血清Hcy水平明显高于B组,P<0.05。预后良好组患者的年龄、NIHSS评分、Hcy水平均明显低于预后不良组,P<0.05。结论 H型高血压患者血清Hcy水平较正常人群明显升高,尤其是合并AIS患者。在合并AIS的H型高血压患者中,年龄、NIHSS评分及Hcy水平是其预后不良的重要影响因素,故对于该病患者,需积极控制其血压水平,同时给予降低Hcy的治疗,以改善其预后。
Objective:To analyze the changes of homocysteine(Hcy)level in patients with H-type hypertension complicated with acute ischemic stroke(AIS)and the influencing factors of prognosis.Methods:From April 2019 to April 2021,260 patients with H-type hypertension were selected,including 125 patients with H-type hypertension complicated with AIS(group A)and 135 patients with pure H-type hypertension(group B).According to the prognosis,group A was divided into two subgroups:good prognosis group(69 cases)and poor prognosis group(56 cases).100 healthy people who underwent physical examination in the hospital outpatient department at the same time were selected(control group).All patients were given routine treatment,and the prognosis of patients with H-type hypertension complicated with AIS was analyzed by univariate and multivariate Logistic regression.Results:The serum Hcy levels in group A and group B were significantly higher than those in the control group,and the serum Hcy level in group A was significantly higher than that in group B,P<0.05.The age、NIHSS score and Hcy level of patients with good prognosis were significantly lower than those with poor prognosis,P<0.05.Conclusion:Serum Hcy level in patients with H-type hypertension is significantly higher than that in normal people,especially in patients with AIS.In patients with H-type hypertension complicated with AIS,age,NIHSS score and Hcy level are important influencing factors for their poor prognosis,so it is necessary to actively control their blood pressure level and give treatment to reduce Hcy to improve their prognosis.
作者
刘玉珂
李建蕾
刘玉婷
Liu Yuke;Li Jianlei;Liu Yuting(Shandong Provincial Third Hospital Disinfection Supply Center,Jinan Shandong 250000,China;Respiratory and Critical Care Seven Wards of Shandong Provincial Public Health Clinical Center,Jinan Shandong 250000,China;Pharmacy Department of Shandong Provincial Hospital of Traditional Chinese Medicine,Jinan Shandong 250000,China)
出处
《生命科学仪器》
2024年第5期188-190,共3页
Life Science Instruments
